Orexin receptor 2 (OX2R) in complex with G protein and small-molecule agonist compound 1

Structure

electron microscopy · 6 distinct chains.

Ligands and binding sites

• XGD · 4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl) phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7L1V · Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 · the same entry in another collection · chain S against S, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt Q548Y0
• Elsewhere: RCSB PDB 7L1V · PDBe 7L1V · UniProt P62873 · UniProt P59768 · UniProt Q548Y0