UniProt Q548Y0
Hypocretin receptor type 2 (Q548Y0)
Hypocretin receptor type 2 (UniProt Q548Y0): 10 experimental structures on GenesisL1, 7 ligands bound, 62 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q548Y0
- Protein
- Hypocretin receptor type 2
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 62 · 10 records with a druggable one
Structures
10 records of Q548Y0 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6TPG | Crystal structure of the Orexin-2 receptor in complex with EMPA at 2.74 A resolution | x-ray diffraction | A | 7MA, OLA | 7 (best 0.82) |
| 6TPG | Crystal structure of the orexin-2 receptor in complex with empa at 2.74 a resolution | x-ray diffraction | A | 7MA, OLA | 7 (best 0.82) |
| 6TPJ | Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution | x-ray diffraction | A, B | OLA, SUV, NH4 | 13 (best 0.83) |
| 6TPJ | Crystal structure of the orexin-2 receptor in complex with suvorexant at 2.76 a resolution | x-ray diffraction | A, B | OLA, SUV, NH4 | 13 (best 0.83) |
| 7L1U | Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) | electron microscopy | R | — | 3 (best 0.70) |
| 7L1U | Orexin receptor 2 (OX2R) in complex with G protein and natural peptide-agonist orexin B (oxb) | electron microscopy | R | NH2 | 3 (best 0.70) |
| 7L1V | Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 | electron microscopy | R | XGD | 4 (best 0.87) |
| 7L1V | Orexin receptor 2 (OX2R) in complex with G protein and small-molecule agonist compound 1 | electron microscopy | R | XGD | 4 (best 0.87) |
| 7SR8 | Molecular mechanism of the the wake-promoting agent TAK-925 | electron microscopy | R | A6F, OLA | 4 (best 0.81) |
| 7SR8 | Molecular mechanism of the the wake-promoting agent tak-925 | electron microscopy | R | A6F, OLA | 4 (best 0.81) |
Ligands
- OLA · Oleic acid · in 6 records
- 7MA · N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl) sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide · in 2 records
- A6F · methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate · in 2 records
- NH4 · Ammonium ion · in 2 records
- SUV · [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl) phenyl]methanone · in 2 records
- XGD · 4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl) phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide · in 2 records
- NH2 · Amino group · in 1 record
Experiment against prediction
- 6TPJ chain B against the predicted model O43614: TM-score 0.65, RMSD 2.27 Å
- 6TPJ chain B against the predicted model O43614: TM-score 0.65, RMSD 2.27 Å
- 6TPJ chain A against the predicted model O43614: TM-score 0.65, RMSD 2.12 Å
- 6TPJ chain A against the predicted model O43614: TM-score 0.65, RMSD 2.12 Å
- 6TPG chain A against the predicted model O43614: TM-score 0.64, RMSD 2.52 Å
- 6TPG chain A against the predicted model O43614: TM-score 0.64, RMSD 2.52 Å
Elsewhere
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