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Ligand · A6F

A6F · methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate

A6F, methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (C21 H32 N2 O5 S, 424.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding…

Component
A6F
Formula
C21 H32 N2 O5 S
Class
ligand
Structures
3
PDB entries
2

Binding sites

A6F in 3 structures; the first of them:

  • 7SR8 · Molecular mechanism of the the wake-promoting agent TAK-925 · A6F R501 · binds CYS107, ALA110, THR111, VAL114, TRP120, PRO131, GLN134, THR135 and 9 more
  • 7SQO · Structure of the orexin-2 RECEPTOR(OX2R) bound to tak-925, gi and SCFV16 · A6F R505 · binds ALA110, THR111, VAL114, PRO131, GLN134, THR135, VAL138, GLN187 and 6 more
  • 7SR8 · Molecular mechanism of the the wake-promoting agent tak-925 · A6F R501 · binds ALA110, THR111, VAL114, TRP120, PRO131, GLN134, THR135, VAL138 and 5 more

Residues it binds most

THR 3, VAL 3, GLN 3, PHE 3, ALA 3, ASN 3, HIS 3, ILE 3, PRO 3, TRP 2 (residue and the binding sites it lines).

Found with

  • OLA · Oleic acid

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