MolNFT v1 · #179845 · protein
Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain
7KHR: “Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain”. Electron microscopy, 10 ligands (POV, WEV, ADP). MolNFT v1 #179845 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KHR
- Type
- protein
- Length
- 8,212 residues
- Chains
- 32
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31404, P31408, P21282, A0A3Q1M4W9, P11019, Q28029, Q0VCV6, F1MZL6, F1MJV0, Q2TA24, P61420, Q2KIB5, P40682, P81134, P23956, Q3ZC23
- Ligands
- POV, WEV, ADP, WJP, OLA, NAG, MAN, GLC, BMA, MG
Structure
electron microscopy · 21 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 589 | — | P31404 |
| B | — | protein | 591 | — | P31404 |
| C | — | protein | 600 | — | P31404 |
| D | — | protein | 461 | — | P31408 |
| E, F | — | protein | 458 | — | P31408 |
| G | — | protein | 346 | — | P21282 |
| H | — | protein | 212 | — | A0A3Q1M4W9 |
| I, J | — | protein | 218 | — | P11019 |
| K | — | protein | 220 | — | P11019 |
| L | — | protein | 103 | — | Q28029 |
| M, N, O | — | protein | 109 | — | Q0VCV6 |
| P | — | protein | 368 | — | F1MZL6 |
| a | — | protein | 750 | — | F1MJV0 |
| b | — | protein | 204 | — | Q2TA24 |
| d | — | protein | 348 | — | P61420 |
| e | — | protein | 73 | — | Q2KIB5 |
| s | — | protein | 204 | — | P40682 |
| r | — | protein | 46 | — | P81134 |
| c, g, k, l, m, n | — | protein | 150 | — | P23956 |
| o, p, q | — | protein | 151 | — | P23956 |
| f | — | protein | 65 | — | Q3ZC23 |
Ligands and binding sites
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 8 copies · chains b, s, r, g, k, c, p, q, n, o, m, l
- WEV · (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S, 4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7, 9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12, 14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose · ligand · 6 copies · chains c, g, k, l, m, o, p, q
- ADP · Adenosine-5'-diphosphate · ligand · chains C, F
- WJP · Methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6, 10,14,18-tetraen-1-yl dihydrogen diphosphate · ligand · chains a, n
- OLA · Oleic acid · ligand · chains r, o, p
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains a, e, s, b
- MAN · alpha-D-mannopyranose · sugar · 5 copies · chains a, e
- GLC · alpha-D-glucopyranose · sugar · 3 copies · chains a
- BMA · beta-D-mannopyranose · sugar · chains a
- MG · Magnesium ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7KHR · Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31404
- Every structure of UniProt P31408
- Every structure of UniProt P21282
- Every structure of UniProt A0A3Q1M4W9
- Every structure of UniProt P11019
- Every structure of UniProt Q28029
- Every structure of UniProt Q0VCV6
- Every structure of UniProt F1MZL6
- Every structure of UniProt F1MJV0
- Every structure of UniProt Q2TA24
- Every structure of UniProt P61420
- Every structure of UniProt Q2KIB5
- Every structure of UniProt P40682
- Every structure of UniProt P81134
- Every structure of UniProt P23956
- Every structure of UniProt Q3ZC23
- Elsewhere: RCSB PDB 7KHR · PDBe 7KHR · UniProt P31404 · UniProt P31408 · UniProt P21282 · UniProt A0A3Q1M4W9 · UniProt P11019 · UniProt Q28029 · UniProt Q0VCV6 · UniProt F1MZL6 · UniProt F1MJV0 · UniProt Q2TA24 · UniProt P61420 · UniProt Q2KIB5 · UniProt P40682 · UniProt P81134 · UniProt P23956 · UniProt Q3ZC23
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