WEV · (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S, 4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7, 9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12, 14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose

Binding sites

WEV in 3 structures; the first of them:

• 7KHR · Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain · WEV g201 · binds LEU133, ILE136, PHE137, VAL140, TYR144, MET53, LYS54, ILE56 and 5 more
• 7TAO · Cryo-EM structure of bafilomycin A1 bound to yeast VO V-ATPase · WEV D201 · binds MET57, LYS58, LEU60, ILE61, VAL64, GLY67, ILE68, ILE71 and 8 more
• 7KHR · Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain · WEV g201 · binds LEU133, PHE137, TYR144, MET53, ILE56, ILE57, VAL60, ILE64
• 7TAO · Cryo-EM structure of bafilomycin A1 bound to yeast vo V-ATPase · WEV D201 · binds MET57, LYS58, ILE61, VAL64, ILE71, VAL186, ILE189, PHE190 and 4 more

Residues it binds most

ILE 30, VAL 29, PHE 30, LEU 27, TYR 27, GLY 17, MET 14, LYS 9, ALA 2 (residue and the binding sites it lines).

Found with

• ADP · Adenosine-5'-diphosphate
• OLA · Oleic acid
• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
• WJP · Methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6, 10,14,18-tetraen-1-yl dihydrogen diphosphate
• MG · Magnesium ion
• BMA · beta-D-mannopyranose
• GLC · alpha-D-glucopyranose
• MAN · alpha-D-mannopyranose
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose