MolNFT v1 · #17945 · protein
Complex between rabbit muscle alpha-actin: human gelsolin residues VAL26-GLU156
1P8Z · Gelsolin precursor, plasma: “Complex between rabbit muscle alpha-actin: human gelsolin residues VAL26-GLU156”. X-ray diffraction, 3 ligands (ATP, CD, CA), 3 pockets (best druggability 0.74). MolNFT v1 #17945 on GenesisL1: 3D…
- PDB
- 1P8Z
- Type
- protein
- Length
- 485 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gelsolin precursor, plasma; Actin, alpha skeletal muscle
- UniProt
- P06396, P68135
- Ligands
- ATP, CD, CA
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Gelsolin precursor, plasma | protein | 131 | 23% helix, 31% strand | P06396 |
| A | Actin, alpha skeletal muscle | protein | 354 | 45% helix, 21% strand | P68135 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- CD · Cadmium ion · metal · 3 copies · chains G, A
- CA · Calcium ion · metal · chains G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.74 | 0.84 | 56 | CD, ATP |
| 2 | 184 | 0.56 | 0.80 | 28 | empty |
| 3 | 217 | 0.48 | 0.75 | 40 | empty |
Interfaces
1 interface between chains.
- G–A · 1397 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 1P8Z · Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156 · the same entry in another collection · chain G against G, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain G against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06396
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 1P8Z · PDBe 1P8Z · UniProt P06396 · UniProt P68135
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