Crystal structure of HRAS in complex with the RAS-binding and cysteine-rich domains of craf-kinase

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 34% strand (DSSP).

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
• ZN · Zinc ion · metal · 2 copies · chains C
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–C · 1204 Ų buried · 25 hydrogen bonds · protein-protein

Compared structures

• 7JHP · Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of… · the same entry in another collection · chain A against A, TM-score 1.00
• P04049 · AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain C against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01112
• Every structure of UniProt P04049
• Elsewhere: RCSB PDB 7JHP · PDBe 7JHP · UniProt P01112 · UniProt P04049