MolNFT v1 · #178647 · protein
Cryo-EM structure of ATP-bound fully inactive ampk in complex with Fab and nanobody
7JHH: “Cryo-EM structure of ATP-bound fully inactive ampk in complex with Fab and nanobody”. Electron microscopy, 4 ligands (ATP, ADP, AMP). MolNFT v1 #178647 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JHH
- Type
- protein
- Length
- 1,698 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q13131, O43741, P54619, C3SHQ8
- Ligands
- ATP, ADP, AMP, GLC
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 379 | — | Q13131 |
| B | — | protein | 93 | — | O43741 |
| G | — | protein | 300 | — | P54619 |
| M | — | protein | 367 | — | C3SHQ8 |
| L | — | protein | 211 | — | — |
| H | — | protein | 228 | — | — |
| N | — | protein | 120 | — | — |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains G
- ADP · Adenosine-5'-diphosphate · ligand · chains G
- AMP · Adenosine monophosphate · ligand · chains G
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains M
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7JHH · Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody · the same entry in another collection · chain N against N, TM-score 1.00
- P54619 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1… · a predicted model of the same protein · chain G against A, TM-score 0.96
- O43741 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit beta-2… · a predicted model of the same protein · chain B against A, TM-score 0.79
- Q13131 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13131
- Every structure of UniProt O43741
- Every structure of UniProt P54619
- Every structure of UniProt C3SHQ8
- Elsewhere: RCSB PDB 7JHH · PDBe 7JHH · UniProt Q13131 · UniProt O43741 · UniProt P54619 · UniProt C3SHQ8
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