UniProt O43741
5'-AMP-activated protein kinase subunit beta-2 (O43741)
5'-AMP-activated protein kinase subunit beta-2 (UniProt O43741): 33 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O43741
- Protein
- 5'-AMP-activated protein kinase subunit beta-2
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 27 · 4 records with a druggable one
Structures
34 records of O43741 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2F15 | Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit | x-ray diffraction | A | — | — |
| 2F15 | Glycogen-binding domain of the AMP-activated protein kinase BETA2 subunit | x-ray diffraction | A | — | — |
| 2V8Q | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP | x-ray diffraction | B | — | — |
| 2V8Q | Crystal structure of the regulatory fragment of mammalian ampk in complexes with AMP | x-ray diffraction | B | — | — |
| 2V92 | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP | x-ray diffraction | B | — | — |
| 2V92 | Crystal structure of the regulatory fragment of mammalian ampk in complexes with ATP-AMP | x-ray diffraction | B | — | — |
| 2V9J | Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP | x-ray diffraction | B | — | — |
| 2V9J | Crystal structure of the regulatory fragment of mammalian ampk in complexes with MG.ATP-AMP | x-ray diffraction | B | — | — |
| 2Y8L | Structure of the regulatory fragment of mammalian aMPK in complex with two ADP | x-ray diffraction | B | — | — |
| 2Y8L | Structure of the regulatory fragment of mammalian ampk in complex with two ADP | x-ray diffraction | B | — | — |
| 2Y8Q | Structure of the regulatory fragment of mammalian AMPK in complex with one ADP | x-ray diffraction | B | — | — |
| 2Y8Q | Structure of the regulatory fragment of mammalian ampk in complex with one ADP | x-ray diffraction | B | — | — |
| 2YA3 | Structure of the regulatory fragment of mammalian ampk in complex with coumarin ADP | x-ray diffraction | B | — | — |
| 2YA3 | Structure of the regulatory fragment of mammalian ampk in complex with coumarin ADP | x-ray diffraction | B | — | — |
| 4CFH | Structure of an active form of mammalian AMPK | x-ray diffraction | B | — | — |
| 4CFH | Structure of an active form of mammalian ampk | x-ray diffraction | B | — | — |
| 4EAI | Co-crystal structure of an AMPK core with AMP | x-ray diffraction | B | — | — |
| 4EAI | Co-crystal structure of an ampk core with AMP | x-ray diffraction | B | — | — |
| 4EAJ | Co-crystal of AMPK core with AMP soaked with ATP | x-ray diffraction | B | — | — |
| 4EAJ | Co-crystal of ampk core with AMP soaked with ATP | x-ray diffraction | B | — | — |
| 4RER | Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP… | x-ray diffraction | B | — | — |
| 4RER | Crystal structure of the phosphorylated human ALPHA1 BETA2 GAMMA1 holo-ampk complex bound to AMP… | x-ray diffraction | B | — | — |
| 4REW | Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex | x-ray diffraction | B | — | — |
| 4REW | Crystal structure of the non-phosphorylated human ALPHA1 BETA2 GAMMA1 holo-ampk complex | x-ray diffraction | B | — | — |
| 6B2E | Structure of full length human ampk (A2B2G1) in complex with a small molecule activator SC4. | x-ray diffraction | B | GLC, CG7 | — |
| 7JHG | Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and… | electron microscopy | B | — | 6 (best 0.85) |
| 7JHG | Cryo-EM structure of ATP-bound fully inactive ampk in complex with dorsomorphin (compound C) and… | electron microscopy | B | — | — |
| 7JHH | Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody | electron microscopy | B | — | 6 (best 0.86) |
| 7JHH | Cryo-EM structure of ATP-bound fully inactive ampk in complex with Fab and nanobody | electron microscopy | B | — | — |
| 7JIJ | ATP-bound AMP-activated protein kinase | x-ray diffraction | B | — | 9 (best 0.86) |
| 7JIJ | ATP-bound AMP-activated protein kinase | x-ray diffraction | B | — | — |
| 7M74 | ATP-bound AMP-activated protein kinase | electron microscopy | B | — | 6 (best 0.83) |
| 7M74 | ATP-bound AMP-activated protein kinase | electron microscopy | B | — | — |
| O43741 | AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit beta-2 (O43741) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4CFH chain B against the predicted model O43741: TM-score 0.98, RMSD 0.46 Å
- 4CFH chain B against the predicted model O43741: TM-score 0.98, RMSD 0.46 Å
- 2F15 chain A against the predicted model O43741: TM-score 0.89, RMSD 1.19 Å
- 2F15 chain A against the predicted model O43741: TM-score 0.89, RMSD 1.19 Å
- 4EAI chain B against the predicted model O43741: TM-score 0.87, RMSD 1.37 Å
- 4EAI chain B against the predicted model O43741: TM-score 0.87, RMSD 1.37 Å
- 4EAJ chain B against the predicted model O43741: TM-score 0.87, RMSD 1.41 Å
- 4EAJ chain B against the predicted model O43741: TM-score 0.87, RMSD 1.41 Å
- 6B2E chain B against the predicted model O43741: TM-score 0.86, RMSD 1.68 Å
- 4REW chain B against the predicted model O43741: TM-score 0.85, RMSD 1.31 Å
Elsewhere
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