Structure of full length human ampk (A2B2G1) in complex with a small molecule activator SC4.

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• AMP · Adenosine monophosphate · ligand · 2 copies · chains A, C
• STU · Staurosporine · ligand · chains A
• CG7 · 5-{[6-chloro-5-(2'-hydroxy[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl]oxy}-2-methylbenzoic acid · ligand · chains A, B
• GLC · alpha-D-glucopyranose · sugar · 7 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6B2E · Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator… · the same entry in another collection · chain A against A, TM-score 1.00
• P54619 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1… · a predicted model of the same protein · chain C against A, TM-score 0.96
• P54646 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95
• O43741 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit beta-2… · a predicted model of the same protein · chain B against A, TM-score 0.86

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• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P54646
• Every structure of UniProt O43741
• Every structure of UniProt P54619
• Elsewhere: RCSB PDB 6B2E · PDBe 6B2E · UniProt P54646 · UniProt O43741 · UniProt P54619