UniProt P54619
5'-AMP-activated protein kinase subunit gamma-1 (P54619)
5'-AMP-activated protein kinase subunit gamma-1 (UniProt P54619): 37 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P54619
- Protein
- 5'-AMP-activated protein kinase subunit gamma-1
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 52 · 6 records with a druggable one
Structures
38 records of P54619 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2UV4 | Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex… | x-ray diffraction | A | — | — |
| 2UV4 | Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk in complex… | x-ray diffraction | A | — | — |
| 2UV5 | Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex… | x-ray diffraction | A | — | — |
| 2UV5 | Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk in complex… | x-ray diffraction | A | — | — |
| 2UV6 | Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex… | x-ray diffraction | A | — | — |
| 2UV6 | Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk in complex… | x-ray diffraction | A | — | — |
| 2UV7 | Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex… | x-ray diffraction | A | — | — |
| 2UV7 | Crystal structure of a cbs domain pair from the regulatory GAMMA1 subunit of human ampk in complex… | x-ray diffraction | A | — | — |
| 4CFE | Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole… | x-ray diffraction | E, F | — | — |
| 4CFE | Structure of full length human ampk in complex with a small molecule activator, a benzimidazole… | x-ray diffraction | E, F | — | — |
| 4CFF | Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone… | x-ray diffraction | E, F | — | — |
| 4CFF | Structure of full length human ampk in complex with a small molecule activator, a thienopyridone… | x-ray diffraction | E, F | — | — |
| 4RER | Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP… | x-ray diffraction | G | — | — |
| 4RER | Crystal structure of the phosphorylated human ALPHA1 BETA2 GAMMA1 holo-ampk complex bound to AMP… | x-ray diffraction | G | — | — |
| 4REW | Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex | x-ray diffraction | G | — | — |
| 4REW | Crystal structure of the non-phosphorylated human ALPHA1 BETA2 GAMMA1 holo-ampk complex | x-ray diffraction | G | — | — |
| 4ZHX | Novel binding site for allosteric activation of ampk | x-ray diffraction | E, F | — | — |
| 5EZV | X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera… | x-ray diffraction | E, F | C2Z | — |
| 5EZV | X-ray crystal structure of AMP-activated protein kinase alpha-2/ALPHA- 1 rim chimaera… | x-ray diffraction | E, F | — | — |
| 5ISO | Structure of full length human ampk (non-phosphorylated at T-loop) in complex with a small molecule… | x-ray diffraction | E, F | AMP | 11 (best 0.83) |
| 5ISO | Structure of full length human ampk (non-phosphorylated at T-loop) in complex with a small molecule… | x-ray diffraction | E, F | — | — |
| 6B1U | Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 | x-ray diffraction | E, F | AMP | 11 (best 0.80) |
| 6B1U | Structure of full-length human ampk (A2B1G1) in complex with a small molecule activator SC4 | x-ray diffraction | E, F | AMP | — |
| 6B2E | Structure of full length human ampk (A2B2G1) in complex with a small molecule activator SC4. | x-ray diffraction | C | AMP | — |
| 6C9F | AMP-activated protein kinase bound to pharmacological activator R734 | x-ray diffraction | C | AMP | — |
| 6C9G | AMP-activated protein kinase bound to pharmacological activator R739 | x-ray diffraction | C | AMP | — |
| 6C9H | non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734 | x-ray diffraction | C | AMP | 6 (best 0.85) |
| 6C9H | Non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734 | x-ray diffraction | C | AMP | — |
| 6C9J | AMP-activated protein kinase bound to pharmacological activator R734 | x-ray diffraction | C | AMP | — |
| 7JHG | Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and… | electron microscopy | G | ATP, ADP, AMP | 7 (best 0.85) |
| 7JHG | Cryo-EM structure of ATP-bound fully inactive ampk in complex with dorsomorphin (compound C) and… | electron microscopy | G | ATP, ADP, AMP | — |
| 7JHH | Cryo-EM structure of ATP-bound fully inactive ampk in complex with Fab and nanobody | electron microscopy | G | ATP, ADP, AMP | — |
| 7JIJ | ATP-bound AMP-activated protein kinase | x-ray diffraction | G | ATP, AMP, ADP | — |
| 7M74 | ATP-bound AMP-activated protein kinase | electron microscopy | G | ATP, ADP, AMP | 7 (best 0.83) |
| 7M74 | ATP-bound AMP-activated protein kinase | electron microscopy | G | ATP, ADP, AMP | — |
| 7MYJ | Structure of full length human ampk (A2B1G1) in complex with a small molecule activator MSG011 | x-ray diffraction | E, F | AMP | — |
| 8BIK | Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455 | x-ray diffraction | C, F | AMP | 10 (best 0.84) |
| P54619 | AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase subunit gamma-1 (P54619) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8BIK chain C against the predicted model P54619: TM-score 0.97, RMSD 1.33 Å
- 6C9F chain C against the predicted model P54619: TM-score 0.97, RMSD 1.37 Å
- 8BIK chain F against the predicted model P54619: TM-score 0.97, RMSD 1.32 Å
- 4CFE chain F against the predicted model P54619: TM-score 0.97, RMSD 1.32 Å
- 4CFE chain F against the predicted model P54619: TM-score 0.97, RMSD 1.32 Å
- 5ISO chain E against the predicted model P54619: TM-score 0.97, RMSD 1.36 Å
- 5ISO chain E against the predicted model P54619: TM-score 0.97, RMSD 1.36 Å
- 5ISO chain F against the predicted model P54619: TM-score 0.97, RMSD 1.34 Å
- 5ISO chain F against the predicted model P54619: TM-score 0.97, RMSD 1.34 Å
- 6B1U chain F against the predicted model P54619: TM-score 0.97, RMSD 1.22 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.