Cryo-EM structure of PFTY720-bound sphingosine 1-phosphate receptor 3 in complex with gi protein

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• J89 · (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7EW2 · Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi… · the same entry in another collection · chain S against S, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• Q99500 · AlphaFold monomer V2.0 prediction for sphingosine 1-phosphate receptor 3 (Q99500) · a predicted model of the same protein · chain R against A, TM-score 0.89
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.85
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt Q99500
• Elsewhere: RCSB PDB 7EW2 · PDBe 7EW2 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt Q99500