MolNFT v1 · #17642 · protein
C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I
1OZS · Troponin C, slow skeletal and cardiac muscles: “C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I”. Solution nmr, 1 ligand (CA), 2 pockets (best druggability 0.54). MolNFT v1…
- PDB
- 1OZS
- Type
- protein
- Length
- 93 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles; Troponin I, cardiac muscle
- UniProt
- P63316, P19429
- Ligands
- CA
- Pockets
- 2 · best druggability 0.54
Structure
solution nmr · 2 distinct chains · 37% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac muscles | protein | 73 | 47% helix, 5% strand | P63316 |
| B | Troponin I, cardiac muscle | protein | 20 | 0% helix, 0% strand | P19429 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.54 | 0.83 | 19 | empty |
| 2 | 72 | 0.38 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 465 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1OZS · C-domain of human cardiac troponin C in complex with the inhibitory region of human… · the same entry in another collection · chain A against A, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.74
- P19429 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) · a predicted model of the same protein · chain B against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Every structure of UniProt P19429
- Elsewhere: RCSB PDB 1OZS · PDBe 1OZS · UniProt P63316 · UniProt P19429
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