MolNFT v1 · #175961 · protein
Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97- go complex
7D76: “Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97- go complex”. Electron microscopy, 4 ligands (PLM, CLR, Y01). MolNFT v1 #175961 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7D76
- Type
- protein
- Length
- 874 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P62873, P59768
- Ligands
- PLM, CLR, Y01, GXR
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 215 | — | — |
| B | — | protein | 338 | — | P62873 |
| G | — | protein | 56 | — | P59768 |
| R | — | protein | 265 | — | — |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 3 copies · chains A, R
- CLR · Cholesterol · ligand · 2 copies · chains R
- Y01 · Cholesterol hemisuccinate · ligand · chains R
- GXR · (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S}, 17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14, 15,16-octahydrocyclopenta[a]phenanthren-3-one · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7D76 · Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex · the same entry in another collection · chain A against A, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7D76 · PDBe 7D76 · UniProt P62873 · UniProt P59768
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