Ilers in complex with a tRNA site inhibitor

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• GVU · (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl) oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid · ligand · chains A
• GV6 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate · ligand · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7D5C · IleRS in complex with a tRNA site inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
• P09436 · AlphaFold monomer V2.0 prediction for isoleucine--tRNA ligase, cytoplasmic (P09436) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P09436
• Elsewhere: RCSB PDB 7D5C · PDBe 7D5C · UniProt P09436