UniProt P09436
Isoleucine--tRNA ligase, cytoplasmic (P09436)
Isoleucine--tRNA ligase, cytoplasmic (UniProt P09436), EC 6.1.1.5: 3 experimental structures on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P09436
- Protein
- Isoleucine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.5
- Experimental structures
- 3
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 8 · 1 record with a druggable one
Structures
3 records of P09436 in the MolNFT archive: 3 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7D5C | IleRS in complex with a tRNA site inhibitor | x-ray diffraction | A | GVU, GV6 | 8 (best 0.81) |
| 7D5C | Ilers in complex with a tRNA site inhibitor | x-ray diffraction | A | GVU, GV6 | — |
| P09436 | AlphaFold monomer V2.0 prediction for isoleucine--tRNA ligase, cytoplasmic (P09436) | — | — | — |
Ligands
- GV6 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate · in 2 records
- GVU · (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl) oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid · in 2 records
Elsewhere
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