GL1X · GenesisL1 explorer

Ligand · GV6

GV6 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate

GV6, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate (C16 H25 N6 O8 P, 460.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB…

Component
GV6
Formula
C16 H25 N6 O8 P
Class
ligand
Structures
3
PDB entries
2

Binding sites

GV6 in 3 structures; the first of them:

  • 7D5C · IleRS in complex with a tRNA site inhibitor · GV6 A1002 · binds GLY45, PRO46, PRO47, PHE48, HIS54, GLY56, HIS57, ALA60 and 11 more
  • 8WNJ · Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile-AMP · GV6 A1005 · binds GLY56, PRO57, PRO58, TYR59, HIS65, GLY67, HIS68, LEU70 and 13 more
  • 7D5C · Ilers in complex with a tRNA site inhibitor · GV6 A1002 · binds GLY45, PRO46, PRO47, PHE48, HIS54, GLY56, HIS57, ASP85 and 9 more

Residues it binds most

GLY 3, HIS 3, PRO 3, TRP 3, ASP 3, GLN 3, GLU 3, ILE 3, PHE 3, SER 3 (residue and the binding sites it lines).

Found with

  • GVU · (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl) oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid
  • EDO · 1,2-ethanediol
  • ZN · Zinc ion
  • ACT · Acetate ion
  • GOL · Glycerol

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