MolNFT v1 · #175548 · protein
Structure of mammalian nalcn-FAM155A complex at 2.65 ångström
7CU3 · Sodium leak channel non-selective protein: “Structure of mammalian nalcn-FAM155A complex at 2.65 ångström”. Electron microscopy, 3 ligands (6OU, CLR, NAG), 20 pockets (best druggability 0.86). MolNFT v1 #175548 on GenesisL1: 3D…
- PDB
- 7CU3
- Type
- protein
- Length
- 1,450 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sodium leak channel non-selective protein; Transmembrane protein FAM155A
- UniProt
- Q6Q760, Q8CCS2
- Ligands
- 6OU, CLR, NAG
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium leak channel non-selective protein | protein | 1277 | 67% helix, 2% strand | Q6Q760 |
| B | Transmembrane protein FAM155A | protein | 173 | 38% helix, 3% strand | Q8CCS2 |
Ligands and binding sites
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 12 copies · chains A, B
- CLR · Cholesterol · ligand · 2 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 539 | 0.86 | 0.92 | 49 | empty |
| 2 | 1172 | 0.82 | 0.83 | 99 | 6OU |
| 3 | 478 | 0.77 | 0.85 | 68 | empty |
| 4 | 773 | 0.75 | 0.80 | 48 | 6OU |
| 5 | 451 | 0.70 | 0.80 | 47 | empty |
Interfaces
1 interface between chains.
- A–B · 2557 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
- 7CU3 · Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom · the same entry in another collection · chain A against A, TM-score 1.00
- Q6Q760 · AlphaFold monomer V2.0 prediction for sodium leak channel non- selective protein (Q6Q760) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q8CCS2 · AlphaFold monomer V2.0 prediction for transmembrane protein FAM155A (Q8CCS2) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6Q760
- Every structure of UniProt Q8CCS2
- Elsewhere: RCSB PDB 7CU3 · PDBe 7CU3 · UniProt Q6Q760 · UniProt Q8CCS2
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