Cryo-EM structure of the human cak bound to ICEC0942 at 2.5 ångströms resolution

Structure

electron microscopy · 3 distinct chains.

Ligands and binding sites

• I74 · (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol · ligand · chains J

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7B5O · Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution · the same entry in another collection · chain H against H, TM-score 1.00
• P51946 · AlphaFold monomer V2.0 prediction for cyclin-H (P51946) · a predicted model of the same protein · chain I against A, TM-score 0.99
• P50613 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 7 (P50613) · a predicted model of the same protein · chain J against A, TM-score 0.93
• P51948 · AlphaFold monomer V2.0 prediction for cdk-activating kinase assembly factor MAT1 (P51948) · a predicted model of the same protein · chain H against A, TM-score 0.78

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P51948
• Every structure of UniProt P51946
• Every structure of UniProt P50613
• Elsewhere: RCSB PDB 7B5O · PDBe 7B5O · UniProt P51948 · UniProt P51946 · UniProt P50613