MolNFT v1 · #171410 · protein
Human er membrane protein complex
6Z3W · Er membrane protein complex subunit 1,ER membrane protein…: “Human er membrane protein complex”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #171410 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6Z3W
- Type
- protein
- Length
- 1,906 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Er membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane…
- UniProt
- Q8N766, Q15006, Q9P0I2, Q5J8M3, Q8N4V1, Q9BV81, Q9NPA0, Q9Y3B6, Q5UCC4
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 9 distinct chains · 38% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Er membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1 | protein | 760 | 9% helix, 25% strand | Q8N766 |
| B | Er membrane protein complex subunit 2 | protein | 263 | 79% helix, 0% strand | Q15006 |
| C | Er membrane protein complex subunit 3 | protein | 177 | 84% helix, 0% strand | Q9P0I2 |
| D | Er membrane protein complex subunit 4 | protein | 84 | 80% helix, 0% strand | Q5J8M3 |
| E | Membrane magnesium transporter 1 | protein | 65 | 78% helix, 0% strand | Q8N4V1 |
| F | Er membrane protein complex subunit 6 | protein | 110 | 63% helix, 0% strand | Q9BV81 |
| G | Er membrane protein complex subunit 7 | protein | 100 | 16% helix, 22% strand | Q9NPA0 |
| H | Er membrane protein complex subunit 9 | protein | 183 | 37% helix, 10% strand | Q9Y3B6 |
| I | Er membrane protein complex subunit 10 | protein | 164 | 19% helix, 27% strand | Q5UCC4 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1092 | 0.80 | 0.82 | 126 | empty |
| 2 | 1097 | 0.78 | 0.80 | 100 | empty |
| 3 | 367 | 0.76 | 0.87 | 58 | empty |
| 4 | 757 | 0.76 | 0.81 | 95 | empty |
| 5 | 1091 | 0.71 | 0.75 | 101 | empty |
Interfaces
13 interfaces between chains.
- B–C · 491 Ų buried · 0 hydrogen bonds · protein-protein
- B–H · 338 Ų buried · 0 hydrogen bonds · protein-protein
- A–I · 310 Ų buried · 2 hydrogen bonds · protein-protein
- C–G · 148 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 143 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6Z3W · Human ER membrane protein complex · the same entry in another collection · chain I against I, TM-score 1.00
- Q15006 · AlphaFold monomer V2.0 prediction for er membrane protein complex subunit 2 (Q15006) · a predicted model of the same protein · chain B against A, TM-score 0.86
- Q9Y3B6 · AlphaFold monomer V2.0 prediction for er membrane protein complex subunit 9 (Q9Y3B6) · a predicted model of the same protein · chain H against A, TM-score 0.81
- Q5UCC4 · AlphaFold monomer V2.0 prediction for er membrane protein complex subunit 10 (Q5UCC4) · a predicted model of the same protein · chain I against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N766
- Every structure of UniProt Q15006
- Every structure of UniProt Q9P0I2
- Every structure of UniProt Q5J8M3
- Every structure of UniProt Q8N4V1
- Every structure of UniProt Q9BV81
- Every structure of UniProt Q9NPA0
- Every structure of UniProt Q9Y3B6
- Every structure of UniProt Q5UCC4
- Elsewhere: RCSB PDB 6Z3W · PDBe 6Z3W · UniProt Q8N766 · UniProt Q15006 · UniProt Q9P0I2 · UniProt Q5J8M3 · UniProt Q8N4V1 · UniProt Q9BV81 · UniProt Q9NPA0 · UniProt Q9Y3B6 · UniProt Q5UCC4
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