MolNFT v1 · #171163 · protein
CWC22-CWC27-EIF4A3 complex
6YVH · Pre-mRNA-splicing factor CWC22 homolog: “CWC22-CWC27-EIF4A3 complex”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #171163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6YVH
- Type
- protein
- Length
- 1,935 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor CWC22 homolog; Spliceosome-associated protein CWC27 homolog…
- EC
- 3.6.4.13
- UniProt
- Q9HCG8, Q6UX04, P38919
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 54% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Pre-mRNA-splicing factor CWC22 homolog | protein | 274 | 69% helix, 1% strand | Q9HCG8 |
| C, I, E | Spliceosome-associated protein CWC27 homolog | protein | 49 | 49% helix, 0% strand | Q6UX04 |
| F | Pre-mRNA-splicing factor CWC22 homolog | protein | 272 | 70% helix, 1% strand | Q9HCG8 |
| H | Eukaryotic initiation factor 4A-III (EC 3.6.4.13) | protein | 162 | 36% helix, 24% strand | P38919 |
| J, L | Eukaryotic initiation factor 4A-III (EC 3.6.4.13) | protein | 162 | 36% helix, 24% strand | P38919 |
| K | Eukaryotic initiation factor 4A-III (EC 3.6.4.13) | protein | 164 | 37% helix, 23% strand | P38919 |
| G | Spliceosome-associated protein CWC27 homolog | protein | 44 | 61% helix, 0% strand | Q6UX04 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 825 | 0.80 | 0.83 | 95 | empty |
| 2 | 1027 | 0.78 | 0.79 | 92 | empty |
| 3 | 410 | 0.68 | 0.80 | 33 | empty |
| 4 | 498 | 0.65 | 0.77 | 57 | empty |
| 5 | 489 | 0.65 | 0.77 | 48 | empty |
Interfaces
16 interfaces between chains.
- F–G · 1634 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 1481 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 1473 Ų buried · 13 hydrogen bonds · protein-protein
- A–I · 1470 Ų buried · 19 hydrogen bonds · protein-protein
- A–H · 1303 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6YVH · CWC22-CWC27-EIF4A3 Complex · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HCG8
- Every structure of UniProt Q6UX04
- Every structure of UniProt P38919
- Elsewhere: RCSB PDB 6YVH · PDBe 6YVH · UniProt Q9HCG8 · UniProt Q6UX04 · UniProt P38919
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