UniProt Q9HCG8
Pre-mRNA-splicing factor CWC22 homolog (Q9HCG8)
Pre-mRNA-splicing factor CWC22 homolog (UniProt Q9HCG8): 38 experimental structures and 1 predicted model on GenesisL1, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9HCG8
- Protein
- Pre-mRNA-splicing factor CWC22 homolog
- Experimental structures
- 38
- Predicted models
- 1
- Pockets
- 34 · 16 records with a druggable one
Structures
39 records of Q9HCG8 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C9B | Crystal structure of eIF4AIII-CWC22 complex | x-ray diffraction | B | — | — |
| 4C9B | Crystal structure of EIF4AIII-CWC22 complex | x-ray diffraction | B | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | T | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | T | — | — |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | V | — | — |
| 5YZG | The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | electron microscopy | V | — | 1 (best 0.85) |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | V | — | — |
| 5Z57 | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | electron microscopy | V | — | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | electron microscopy | V | — | 1 (best 0.82) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | V | — | — |
| 6FF7 | human Bact spliceosome core structure | electron microscopy | T | — | 1 (best 0.81) |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | T | — | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | electron microscopy | V | — | 1 (best 0.83) |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | V | — | — |
| 6QDV | Human post-catalytic P complex spliceosome | electron microscopy | H | — | 1 (best 0.84) |
| 6YVH | CWC22-CWC27-EIF4A3 Complex | x-ray diffraction | A, B, D, F | — | 15 (best 0.80) |
| 6YVH | CWC22-CWC27-EIF4A3 complex | x-ray diffraction | A, B, D, F | — | — |
| 6ZYM | Human C Complex Spliceosome - High-resolution CORE | electron microscopy | T | — | 1 (best 0.83) |
| 6ZYM | Human C complex spliceosome - high-resolution core | electron microscopy | T | — | — |
| 7A5P | Human C Complex Spliceosome - Medium-resolution PERIPHERY | electron microscopy | T | — | — |
| 7A5P | Human C complex spliceosome - medium-resolution periphery | electron microscopy | T | — | — |
| 7DVQ | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | electron microscopy | V | — | 1 (best 0.85) |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | V | — | — |
| 7QTT | Structural organization of a late activated human spliceosome (Baqr, core region) | electron microscopy | W | — | — |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | V | — | 2 (best 0.83) |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | V | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | V | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | V | — | — |
| 7W5B | The cryo-EM structure of human C* complex | electron microscopy | V | — | 2 (best 0.87) |
| 8C6J | Human spliceosomal PM5 C* complex | electron microscopy | H | — | — |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | W | — | — |
| 8I0R | The cryo-EM structure of human Bact-I complex | electron microscopy | V | — | 2 (best 0.82) |
| 8I0S | The cryo-EM structure of human Bact-II complex | electron microscopy | V | — | 1 (best 0.83) |
| 8I0T | The cryo-EM structure of human Bact-III complex | electron microscopy | V | — | — |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | V | — | 1 (best 0.81) |
| 8I0V | The cryo-EM structure of human post-Bact complex | electron microscopy | V | — | 1 (best 0.82) |
| 8I0W | The cryo-EM structure of human C complex | electron microscopy | V | — | 2 (best 0.80) |
| 9FMD | Integrative model of the human post-catalytic spliceosome (P-complex) | electron microscopy | H | — | 1 (best 0.82) |
| Q9HCG8 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWC22 homolog (Q9HCG8) | predicted | A | — | — |
Experiment against prediction
- 7A5P chain T against the predicted model Q9HCG8: TM-score 0.99, RMSD 0.58 Å
- 7A5P chain T against the predicted model Q9HCG8: TM-score 0.99, RMSD 0.58 Å
- 6YVH chain F against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.21 Å
- 6YVH chain F against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.22 Å
- 6YVH chain D against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.26 Å
- 6YVH chain D against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.26 Å
- 6YVH chain A against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.30 Å
- 6YVH chain A against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.30 Å
- 6YVH chain B against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.32 Å
- 6YVH chain B against the predicted model Q9HCG8: TM-score 0.97, RMSD 1.32 Å
Elsewhere
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