Research workbench

CWC22-CWC27-EIF4A3 complex

Analyse CWC22-CWC27-EIF4A3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6YVH
Type: protein
Length: 1,935 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing factor CWC22 homolog; Spliceosome-associated protein CWC27 homolog…
EC: 3.6.4.13
UniProt: Q9HCG8, Q6UX04, P38919
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 7 distinct chains · 54% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	Pre-mRNA-splicing factor CWC22 homolog	protein	274	69% helix, 1% strand	Q9HCG8
C, I, E	Spliceosome-associated protein CWC27 homolog	protein	49	49% helix, 0% strand	Q6UX04
F	Pre-mRNA-splicing factor CWC22 homolog	protein	272	70% helix, 1% strand	Q9HCG8
H	Eukaryotic initiation factor 4A-III (EC 3.6.4.13)	protein	162	36% helix, 24% strand	P38919
J, L	Eukaryotic initiation factor 4A-III (EC 3.6.4.13)	protein	162	36% helix, 24% strand	P38919
K	Eukaryotic initiation factor 4A-III (EC 3.6.4.13)	protein	164	37% helix, 23% strand	P38919
G	Spliceosome-associated protein CWC27 homolog	protein	44	61% helix, 0% strand	Q6UX04

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	825	0.80	0.83	95	empty
2	1027	0.78	0.79	92	empty
3	410	0.68	0.80	33	empty
4	498	0.65	0.77	57	empty
5	489	0.65	0.77	48	empty

Interfaces

16 interfaces between chains.

F–G · 1634 Å² buried · 19 hydrogen bonds · protein-protein
B–C · 1481 Å² buried · 13 hydrogen bonds · protein-protein
D–E · 1473 Å² buried · 13 hydrogen bonds · protein-protein
A–I · 1470 Å² buried · 19 hydrogen bonds · protein-protein
A–H · 1303 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

6YVH · CWC22-CWC27-EIF4A3 Complex · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HCG8
Every structure of UniProt Q6UX04
Every structure of UniProt P38919
Elsewhere: RCSB PDB 6YVH · PDBe 6YVH · UniProt Q9HCG8 · UniProt Q6UX04 · UniProt P38919

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