Crystal structure of the camp-dependent protein kinase a in complex with aminofasudil and pki (5-24)

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• LRT · 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine · ligand · chains A
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A, B
• DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
• MRD · (4R)-2-methylpentane-2,4-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6YNT · Crystal structure of the cAMP-dependent protein kinase A in complex with aminofasudil and… · the same entry in another collection · chain A against A, TM-score 1.00
• P63248 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase inhibitor alpha… · a predicted model of the same protein · chain B against A, TM-score 0.42

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25321
• Every structure of UniProt P63248
• Elsewhere: RCSB PDB 6YNT · PDBe 6YNT · UniProt P25321 · UniProt P63248