UniProt P63248
cAMP-dependent protein kinase inhibitor alpha (P63248)
cAMP-dependent protein kinase inhibitor alpha (UniProt P63248): 72 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P63248
- Protein
- cAMP-dependent protein kinase inhibitor alpha
- Experimental structures
- 72
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 14 · 11 records with a druggable one
Structures
73 records of P63248 in the MolNFT archive: 72 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1APM | 2.0 ångström refined crystal structure of the catalytic subunit of camp-dependent protein kinase… | x-ray diffraction | I | — | — |
| 1APM | 2.0 ångström refined crystal structure of the catalytic subunit of camp-dependent protein kinase… | x-ray diffraction | I | — | — |
| 1ATP | 2.2 angstrom refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase… | x-ray diffraction | I | — | — |
| 1ATP | 2.2 ångström refined crystal structure of the catalytic subunit of camp-dependent protein kinase… | x-ray diffraction | I | — | — |
| 2CPK | Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein… | x-ray diffraction | I | — | — |
| 2CPK | Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein… | x-ray diffraction | I | — | — |
| 2QUR | Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase | x-ray diffraction | B | — | — |
| 2QUR | Crystal structure of F327A/K285P mutant of camp-dependent protein kinase | x-ray diffraction | B | — | — |
| 3FJQ | Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide… | x-ray diffraction | I | — | — |
| 3FJQ | Crystal structure of camp-dependent protein kinase catalytic subunit alpha in complex with peptide… | x-ray diffraction | I | — | — |
| 3OW3 | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors | x-ray diffraction | B | — | — |
| 3OW3 | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan AKT inhibitors | x-ray diffraction | B | — | — |
| 3ZO2 | The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors | x-ray diffraction | I | — | — |
| 3ZO2 | The synthesis and evaluation of diazaspirocyclic protein kinase inhibitors | x-ray diffraction | I | — | — |
| 4DFX | Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DFX | Crystal structure of myristoylated K7C catalytic subunit of camp- dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DFZ | Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DFZ | Crystal structure of myristoylated K7C catalytic subunit of camp- dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DG0 | Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex… | x-ray diffraction | I | — | — |
| 4DG0 | Crystal structure of myristoylated wt catalytic subunit of camp- dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DG2 | Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex… | x-ray diffraction | I | — | — |
| 4DG2 | Crystal structure of myristoylated wt catalytic subunit of camp- dependent protein kinase in… | x-ray diffraction | I | — | — |
| 4DG3 | Crystal structure of R336A mutant of cAMP-dependent protein kinase with unphosphorylated turn motif. | x-ray diffraction | A | — | — |
| 4DG3 | Crystal structure of R336A mutant of camp-dependent protein kinase with unphosphorylated turn motif. | x-ray diffraction | A | — | — |
| 4DH1 | Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with low Mg2+… | x-ray diffraction | I | — | — |
| 4DH1 | Low temperature X-ray structure of camp dependent protein kinase a catalytic subunit with low MG2+… | x-ray diffraction | I | — | — |
| 4DH3 | Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH3 | Low temperature X-ray structure of camp dependent protein kinase a catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH5 | Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH5 | Room temperature X-ray structure of camp dependent protein kinase a catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH7 | Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH7 | Low temperature X-ray structure of camp dependent protein kinase a catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH8 | Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4DH8 | Room temperature X-ray structure of camp dependent protein kinase a catalytic subunit with high… | x-ray diffraction | I | — | — |
| 4HPT | Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete… | x-ray diffraction | I | — | — |
| 4HPT | Crystal structure of the catalytic subunit of camp-dependent protein kinase displaying complete… | x-ray diffraction | I | — | — |
| 4HPU | Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial… | x-ray diffraction | I | — | — |
| 4HPU | Crystal structure of the catalytic subunit of camp-dependent protein kinase displaying partial… | x-ray diffraction | I | — | — |
| 6F14 | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with isoquinoline and PKI… | x-ray diffraction | B | — | 2 (best 0.73) |
| 6F14 | Crystal structure of the camp-dependent protein kinase a cocrystallized with isoquinoline and pki… | x-ray diffraction | B | — | — |
| 6Y05 | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with adenine and PKI (5-24) | x-ray diffraction | B | — | 1 (best 0.79) |
| 6Y05 | Crystal structure of the camp-dependent protein kinase a cocrystallized with adenine and pki (5-24) | x-ray diffraction | B | — | — |
| 6Y0B | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with quinazolin-4-amine and… | x-ray diffraction | B | — | 1 (best 0.76) |
| 6Y0B | Crystal structure of the camp-dependent protein kinase a cocrystallized with quinazolin-4-amine and… | x-ray diffraction | B | — | — |
| 6Y2O | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with… | x-ray diffraction | B | — | 1 (best 0.79) |
| 6Y2O | Crystal structure of the camp-dependent protein kinase a cocrystallized with… | x-ray diffraction | B | — | — |
| 6Y2U | Crystal structure of the camp-dependent protein kinase a cocrystallized with aminofasudil and pki… | x-ray diffraction | B | — | — |
| 6Y89 | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with Methyl… | x-ray diffraction | B | — | 1 (best 0.77) |
| 6Y89 | Crystal structure of the camp-dependent protein kinase a cocrystallized with methyl… | x-ray diffraction | B | — | — |
| 6Y8C | Crystal structure of the camp-dependent protein kinase a cocrystallized with ATP and pki (5-24) | x-ray diffraction | B | — | — |
| 6YNA | Crystal structure of camp-dependent protein kinase (PKA) in complex with fasudil (M77, soaked) | x-ray diffraction | B | — | — |
| 6YNB | Crystal structure of camp-dependent protein kinase (PKA) in complex with short-chain… | x-ray diffraction | B | — | — |
| 6YNC | Crystal structure of camp-dependent protein kinase (PKA) in complex with the methylated… | x-ray diffraction | B | — | — |
| 6YNR | Crystal structure of the camp-dependent protein kinase a in complex with 1,7-naphthyridin-8-amine… | x-ray diffraction | B | — | — |
| 6YNT | Crystal structure of the camp-dependent protein kinase a in complex with aminofasudil and pki (5-24) | x-ray diffraction | B | — | — |
| 6YOT | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with… | x-ray diffraction | B | — | 1 (best 0.77) |
| 6YOT | Crystal structure of the camp-dependent protein kinase a cocrystallized with… | x-ray diffraction | B | — | — |
| 6YPP | Crystal structure of the camp-dependent protein kinase a cocrystallized with pki (5-24). soaking of… | x-ray diffraction | B | — | — |
| 6YQI | Crystal structure of camp-dependent protein kinase (PKA) in complex with long-chain… | x-ray diffraction | B | 6TV | — |
| 6YQJ | Crystal structure of camp-dependent protein kinase (PKA) in complex with open-chain… | x-ray diffraction | B | — | — |
13 records more on the page itself.
Ligands
Experiment against prediction
- 7BB0 chain B against the predicted model P63248: TM-score 0.46, RMSD 2.23 Å
- 7BB0 chain B against the predicted model P63248: TM-score 0.46, RMSD 2.23 Å
- 7AXT chain B against the predicted model P63248: TM-score 0.46, RMSD 2.18 Å
- 6Y05 chain B against the predicted model P63248: TM-score 0.45, RMSD 1.65 Å
- 6Y05 chain B against the predicted model P63248: TM-score 0.45, RMSD 1.65 Å
- 3ZO2 chain I against the predicted model P63248: TM-score 0.44, RMSD 1.56 Å
- 3ZO2 chain I against the predicted model P63248: TM-score 0.44, RMSD 1.56 Å
- 3OW3 chain B against the predicted model P63248: TM-score 0.44, RMSD 1.61 Å
- 3OW3 chain B against the predicted model P63248: TM-score 0.44, RMSD 1.61 Å
- 7PID chain B against the predicted model P63248: TM-score 0.44, RMSD 1.61 Å
Elsewhere
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