UniProt P25321
cAMP-dependent protein kinase catalytic subunit alpha (P25321)
cAMP-dependent protein kinase catalytic subunit alpha (UniProt P25321), EC 2.7.11.11: 192 experimental structures on GenesisL1, 83 ligands bound, 128 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P25321
- Protein
- cAMP-dependent protein kinase catalytic subunit alpha
- EC
- 2.7.11.11
- Experimental structures
- 192
- Predicted models
- 0
- Ligands
- 83
- Pockets
- 128 · 33 records with a druggable one
Structures
192 records of P25321 in the MolNFT archive: 192 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WIH | Crystal structure of cAMP-dependent Protein Kinase A from Cricetulus griseus | x-ray diffraction | A | — | — |
| 4WIH | Crystal structure of camp-dependent protein kinase a from cricetulus griseus | x-ray diffraction | A | — | — |
| 5LCP | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with Fasudil (M77) | x-ray diffraction | A | M77 | 5 (best 0.80) |
| 5LCP | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with fasudil (M77) | x-ray diffraction | A | M77 | — |
| 5LCQ | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with long-chain… | x-ray diffraction | A | 6TV | — |
| 5LCQ | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with long-chain… | x-ray diffraction | A | 6TV | — |
| 5LCR | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with open-chain… | x-ray diffraction | A | 6TX | 4 (best 0.77) |
| 5LCR | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with open-chain… | x-ray diffraction | A | 6TX | — |
| 5LCT | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a R-methyl-piperazine… | x-ray diffraction | A | 6TY | — |
| 5LCT | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a R-methyl-piperazine… | x-ray diffraction | A | 6TY | — |
| 5LCU | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a S-methyl-piperazine… | x-ray diffraction | A | IQP | 6 (best 0.80) |
| 5LCU | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a S-methyl-piperazine… | x-ray diffraction | A | IQP | — |
| 5M0B | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a short-chained… | x-ray diffraction | A | IQU | — |
| 5M0C | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with the fasudil-fragment… | x-ray diffraction | A | 7CB | — |
| 5M0L | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated… | x-ray diffraction | A | 7CT | — |
| 5M0L | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with the methylated… | x-ray diffraction | A | 7CT | — |
| 5M0U | Apostructure structure of cAMP-dependent Protein Kinase (PKA) from CHO cells with a peptidic… | x-ray diffraction | A | — | 4 (best 0.71) |
| 5M0U | Apostructure structure of camp-dependent protein kinase (PKA) from cho cells with a peptidic… | x-ray diffraction | A | — | — |
| 5M6V | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a double methylated… | x-ray diffraction | A | H52 | — |
| 5M6V | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a double methylated… | x-ray diffraction | A | H52 | — |
| 5M6Y | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline… | x-ray diffraction | A | 7KB | 4 (best 0.80) |
| 5M6Y | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a methylisoquinoline… | x-ray diffraction | A | 7KB | — |
| 5M71 | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with an (R)-methyl substitued… | x-ray diffraction | A | 7K7 | — |
| 5M75 | Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a (S)-methyl substitued… | x-ray diffraction | A | 9K6 | — |
| 5M75 | Cocrystal structure of camp-dependent protein kinase (PKA) in complex with a (S)-methyl substitued… | x-ray diffraction | A | 9K6 | — |
| 5MHI | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 7N9 | — |
| 5N1D | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8FZ | — |
| 5N1E | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 9NT | — |
| 5N1E | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 9NT | — |
| 5N1F | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8ET | — |
| 5N1F | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8ET | — |
| 5N1G | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8G5 | 5 (best 0.69) |
| 5N1G | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8G5 | — |
| 5N1H | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8G2 | — |
| 5N1H | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8G2 | — |
| 5N1K | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 489 | — |
| 5N1K | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 489 | — |
| 5N1L | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 47V | — |
| 5N1L | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 47V | — |
| 5N1M | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | BJK | — |
| 5N1M | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | BJK | — |
| 5N1N | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8G8 | — |
| 5N1O | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8GB | 3 (best 0.81) |
| 5N1O | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8GB | — |
| 5N32 | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8K5 | 3 (best 0.77) |
| 5N32 | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8K5 | — |
| 5N33 | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8JW | — |
| 5N33 | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8JW | — |
| 5N36 | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | F05 | — |
| 5N36 | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | F05 | — |
| 5N37 | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8JT | — |
| 5N37 | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8JT | — |
| 5N39 | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8LZ | 2 (best 0.82) |
| 5N39 | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8LZ | — |
| 5N3A | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 46P | — |
| 5N3A | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 46P | — |
| 5N3B | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | BJN | — |
| 5N3B | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | BJN | — |
| 5N3C | cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8M2 | — |
| 5N3C | Camp-dependent protein kinase a from cricetulus griseus in complex with fragment like molecule… | x-ray diffraction | A | 8M2 | — |
132 records more on the page itself.
Ligands
- M77 · 5-(1,4-diazepan-1-sulfonyl)isoquinoline · in 16 records
- RIP · beta-D-ribopyranose · in 12 records
- 9LQ · [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl) methyl]phenyl]boronic acid · in 9 records
- AO8 · [2-[[2-(isoquinolin-5-ylsulfonylamino) ethylamino]methyl]phenyl]boronic acid · in 5 records
- 7KB · 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline · in 4 records
- LRT · 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine · in 4 records
- 6TV · ~{N}-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide · in 3 records
- 6TX · 2-[isoquinolin-5-ylsulfonyl(propyl)amino]ethylazanium · in 3 records
- 7CT · ~{N}-methylisoquinoline-5-sulfonamide · in 3 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- ATP · Adenosine-5'-triphosphate · in 3 records
- ISQ · Isoquinoline · in 3 records
- O72 · 1,7-naphthyridin-8-amine · in 3 records
- 152 · Carnitine · in 2 records
- 1LQ · quinazolin-4-amine · in 2 records
- 1SQ · Isoquinolin-1-amine · in 2 records
- 3AB · 3-aminobenzamide · in 2 records
- 463 · N-[3-(aminomethyl)phenyl]acetamide · in 2 records
- 46L · 6-(dimethylamino)pyridine-3-carboxylic acid · in 2 records
- 46P · 4-methyl-5-(1-methyl-1H-imidazol-2-yl)-1,3-thiazol-2-amine · in 2 records
- 47V · 2,5-dimethyl-N-(pyridin-4-yl)furan-3-carboxamide · in 2 records
- 489 · (1S)-2-amino-1-(4-fluorophenyl)ethanol · in 2 records
- 4NB · 4-nitrobenzoic acid · in 2 records
- 5H1 · 1H-indol-5-ol · in 2 records
- 6TY · 5-[(2~{R})-2-methylpiperazin-1-yl]sulfonylisoquinoline · in 2 records
- 8ET · ~{N}-quinolin-5-ylpyridine-3-carboxamide · in 2 records
- 8G2 · (4-methoxycarbonylphenyl)methylazanium · in 2 records
- 8G5 · (4R)-4-(2-amino-1,3-thiazol-4-yl)-1-oxaspiro[4.5]decan-2-one · in 2 records
- 8GB · 1-[5-chloranyl-3-(chloromethyl)-2-oxidanyl-phenyl]ethanone · in 2 records
- 8JT · 1,3-benzodioxol-5-ylmethyl(cyclopentyl)azanium · in 2 records
Elsewhere
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