MolNFT v1 · #170573 · protein
Structure of a human 48S translational initiation complex - EIF3BGI
6YBT · Eukaryotic translation initiation factor 3 subunit a: “Structure of a human 48S translational initiation complex - EIF3BGI”. Electron microscopy, 15 pockets (best druggability 0.74). MolNFT v1 #170573 on GenesisL1: 3D structure…
- PDB
- 6YBT
- Type
- protein
- Length
- 1,026 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a; Eukaryotic translation initiation…
- UniProt
- Q14152, Q13347, P55884
- Pockets
- 15 · best druggability 0.74
Structure
electron microscopy · 3 distinct chains · 18% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| u | Eukaryotic translation initiation factor 3 subunit a | protein | 134 | 86% helix, 0% strand | Q14152 |
| 2 | Eukaryotic translation initiation factor 3 subunit I | protein | 304 | 2% helix, 33% strand | Q13347 |
| 1 | Eukaryotic translation initiation factor 3 subunit B | protein | 588 | 11% helix, 33% strand | P55884 |
Pockets
15 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 689 | 0.74 | 0.80 | 89 | empty |
| 2 | 175 | 0.73 | 0.90 | 42 | empty |
| 3 | 464 | 0.69 | 0.80 | 49 | empty |
| 4 | 216 | 0.65 | 0.84 | 47 | empty |
| 5 | 320 | 0.65 | 0.81 | 51 | empty |
Interfaces
2 interfaces between chains.
- u–1 · 420 Ų buried · 2 hydrogen bonds · protein-protein
- 2–1 · 275 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6YBT · Structure of a human 48S translational initiation complex - eIF3bgi · the same entry in another collection · chain u against u, TM-score 1.00
- Q13347 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain 2 against A, TM-score 0.87
- P55884 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain 1 against A, TM-score 0.85
- Q14152 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain u against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14152
- Every structure of UniProt Q13347
- Every structure of UniProt P55884
- Elsewhere: RCSB PDB 6YBT · PDBe 6YBT · UniProt Q14152 · UniProt Q13347 · UniProt P55884
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