UniProt Q14152
Eukaryotic translation initiation factor 3 subunit A (Q14152)
Eukaryotic translation initiation factor 3 subunit A (UniProt Q14152): 9 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14152
- Protein
- Eukaryotic translation initiation factor 3 subunit A
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 13 · 6 records with a druggable one
Structures
10 records of Q14152 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | u | — | — |
| 6YBT | Structure of a human 48S translational initiation complex - EIF3BGI | electron microscopy | u | — | — |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | A | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | u | — | 1 (best 0.86) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | u | — | 1 (best 0.84) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | u | — | 2 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | u | — | 1 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | Iu | — | 1 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | u | — | 7 (best 0.87) |
| Q14152 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit a (Q14152) | predicted | A | — | — |
Experiment against prediction
- 6YBD chain u against the predicted model Q14152: TM-score 0.94, RMSD 2.45 Å
- 8PPL chain Iu against the predicted model Q14152: TM-score 0.92, RMSD 2.36 Å
- 8RG0 chain u against the predicted model Q14152: TM-score 0.89, RMSD 2.52 Å
- 7A09 chain A against the predicted model Q14152: TM-score 0.78, RMSD 2.70 Å
- 8PJ1 chain u against the predicted model Q14152: TM-score 0.76, RMSD 2.30 Å
- 7QP6 chain u against the predicted model Q14152: TM-score 0.76, RMSD 2.63 Å
- 7QP7 chain u against the predicted model Q14152: TM-score 0.76, RMSD 2.38 Å
- 8PJ6 chain u against the predicted model Q14152: TM-score 0.76, RMSD 2.45 Å
- 6YBT chain u against the predicted model Q14152: TM-score 0.44, RMSD 3.76 Å
Elsewhere
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