MolNFT v1 · #169060 · protein
Human secretin receptor gs complex
6WZG: “Human secretin receptor gs complex”. Electron microscopy, 14 pockets (best druggability 0.83). MolNFT v1 #169060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WZG
- Type
- protein
- Length
- 1,165 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Secretin; Secretin receptor; Guanine nucleotide-binding protein G(S) subunit alpha…
- UniProt
- P09683, P47872, P63092, P62873, P59768
- Pockets
- 14 · best druggability 0.83
Structure
electron microscopy · 6 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P | Secretin | protein | 27 | 93% helix, 0% strand | P09683 |
| R | Secretin receptor | protein | 379 | 64% helix, 0% strand | P47872 |
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 240 | 48% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 7% helix, 47% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 55 | 53% helix, 0% strand | P59768 |
| N | NANOBODY35 | protein | 126 | 7% helix, 43% strand | — |
Pockets
14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 782 | 0.83 | 0.86 | 58 | empty |
| 2 | 800 | 0.76 | 0.80 | 60 | empty |
| 3 | 291 | 0.72 | 0.85 | 43 | empty |
| 4 | 1048 | 0.71 | 0.75 | 67 | empty |
| 5 | 343 | 0.66 | 0.81 | 58 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2166 Ų buried · 18 hydrogen bonds · protein-protein
- P–R · 1499 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1486 Ų buried · 32 hydrogen bonds · protein-protein
- R–A · 1104 Ų buried · 11 hydrogen bonds · protein-protein
- A–N · 991 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6WZG · Human secretin receptor Gs complex · the same entry in another collection · chain N against N, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
- P47872 · AlphaFold monomer V2.0 prediction for secretin receptor (P47872) · a predicted model of the same protein · chain R against A, TM-score 0.91
- P09683 · AlphaFold monomer V2.0 prediction for secretin (P09683) · a predicted model of the same protein · chain P against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09683
- Every structure of UniProt P47872
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 6WZG · PDBe 6WZG · UniProt P09683 · UniProt P47872 · UniProt P63092 · UniProt P62873 · UniProt P59768
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