MolNFT v1 · #168492 · protein
Human secretin receptor gs complex
6WI9 · Guanine nucleotide-binding protein G(S) subunit alpha…: “Human secretin receptor gs complex”. Electron microscopy, 13 pockets (best druggability 0.84). MolNFT v1 #168492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WI9
- Type
- protein
- Length
- 1,108 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P09683, P47872
- Pockets
- 13 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 194 | 44% helix, 15% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 43% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 55 | 45% helix, 0% strand | P59768 |
| N | NANOBODY35 | protein | 126 | 5% helix, 42% strand | — |
| P | Secretin | protein | 27 | 93% helix, 0% strand | P09683 |
| R | Secretin receptor | protein | 368 | 62% helix, 3% strand | P47872 |
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 870 | 0.84 | 0.86 | 81 | empty |
| 2 | 778 | 0.78 | 0.82 | 89 | empty |
| 3 | 1164 | 0.77 | 0.79 | 82 | empty |
| 4 | 611 | 0.73 | 0.81 | 45 | empty |
| 5 | 712 | 0.71 | 0.78 | 77 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2104 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 1536 Ų buried · 14 hydrogen bonds · protein-protein
- A–R · 1381 Ų buried · 8 hydrogen bonds · protein-protein
- P–R · 1368 Ų buried · 5 hydrogen bonds · protein-protein
- A–N · 855 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6WI9 · Human secretin receptor Gs complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P47872 · AlphaFold monomer V2.0 prediction for secretin receptor (P47872) · a predicted model of the same protein · chain R against A, TM-score 0.87
- P09683 · AlphaFold monomer V2.0 prediction for secretin (P09683) · a predicted model of the same protein · chain P against A, TM-score 0.83
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.80
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P09683
- Every structure of UniProt P47872
- Elsewhere: RCSB PDB 6WI9 · PDBe 6WI9 · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P09683 · UniProt P47872
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