MolNFT v1 · #166480 · protein
Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor in complex with varenicline
6UR8: “Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor in complex with varenicline”. Electron microscopy, 3 ligands (QMR, NAG, BMA). MolNFT v1 #166480 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UR8
- Type
- protein
- Length
- 1,798 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P43681, P0ABE7, P17787
- Ligands
- QMR, NAG, BMA
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | — | protein | 362 | — | P43681, P0ABE7 |
| B, C, E | — | protein | 358 | — | P17787 |
Ligands and binding sites
- QMR · Varenicline · ligand · 2 copies · chains A, B, D, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B, C, D, E
- BMA · beta-D-mannopyranose · sugar · 3 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6UR8 · CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P43681 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-4… · a predicted model of the same protein · chain A against A, TM-score 0.97
- P17787 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit beta-2… · a predicted model of the same protein · chain C against A, TM-score 0.97
- P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43681
- Every structure of UniProt P0ABE7
- Every structure of UniProt P17787
- Elsewhere: RCSB PDB 6UR8 · PDBe 6UR8 · UniProt P43681 · UniProt P0ABE7 · UniProt P17787
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