UniProt P43681
Neuronal acetylcholine receptor subunit alpha-4 (P43681)
Neuronal acetylcholine receptor subunit alpha-4 (UniProt P43681): 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 101 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P43681
- Protein
- Neuronal acetylcholine receptor subunit alpha-4
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 101 · 6 records with a druggable one
Structures
15 records of P43681 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LLY | NMR structures of the transmembrane domains of the nAChR a4 subunit | solution nmr | A | — | — |
| 2LLY | NMR structures of the transmembrane domains of the nachr A4 subunit | solution nmr | A | — | — |
| 5KXI | X-ray structure of the human Alpha4Beta2 nicotinic receptor | x-ray diffraction | A, D | NAG, NCT | — |
| 5KXI | X-ray structure of the human ALPHA4BETA2 nicotinic receptor | x-ray diffraction | A, D | NAG, NCT | — |
| 6CNJ | Structure of the 2ALPHA3BETA stiochiometry of the human ALPHA4BETA2 nicotinic receptor | electron microscopy | A, D | NAG, NCT, Y01 | — |
| 6CNK | Structure of the 3ALPHA2BETA stiochiometry of the human ALPHA4BETA2 nicotinic receptor | electron microscopy | A, B, D | NAG, Y01, NCT | — |
| 6UR8 | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | electron microscopy | A, D | NAG, QMR | 17 (best 0.77) |
| 6UR8 | Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor in complex with varenicline | electron microscopy | A, D | NAG, QMR | — |
| 6USF | Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor with varenicline in complex… | electron microscopy | A, D | NAG, QMR | — |
| 8SSZ | The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in… | electron microscopy | A, D | NAG, ACH, CA | 16 (best 0.82) |
| 8ST0 | The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in… | electron microscopy | A, D | NAG, ACH | 17 (best 0.81) |
| 8ST1 | The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with… | electron microscopy | A, B, D | NAG, ACH, CA | 18 (best 0.80) |
| 8ST2 | The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with… | electron microscopy | A, B, D | NAG, ACH | 18 (best 0.82) |
| 8ST3 | The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with… | electron microscopy | A, D | NAG, ACH, CA | 15 (best 0.82) |
| P43681 | AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-4 (P43681) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8SSZ chain D against the predicted model P43681: TM-score 0.98, RMSD 0.98 Å
- 8ST0 chain D against the predicted model P43681: TM-score 0.98, RMSD 0.98 Å
- 8ST0 chain A against the predicted model P43681: TM-score 0.98, RMSD 1.00 Å
- 8ST1 chain B against the predicted model P43681: TM-score 0.98, RMSD 0.99 Å
- 8ST2 chain B against the predicted model P43681: TM-score 0.98, RMSD 1.02 Å
- 8ST3 chain D against the predicted model P43681: TM-score 0.98, RMSD 1.01 Å
- 8ST2 chain A against the predicted model P43681: TM-score 0.98, RMSD 1.02 Å
- 8ST2 chain D against the predicted model P43681: TM-score 0.98, RMSD 1.02 Å
- 8SSZ chain A against the predicted model P43681: TM-score 0.98, RMSD 1.03 Å
- 8ST3 chain A against the predicted model P43681: TM-score 0.98, RMSD 1.03 Å
Elsewhere
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