UniProt P17787
Neuronal acetylcholine receptor subunit beta-2 (P17787)
Neuronal acetylcholine receptor subunit beta-2 (UniProt P17787): 18 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 69 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P17787
- Protein
- Neuronal acetylcholine receptor subunit beta-2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 69 · 4 records with a druggable one
Structures
19 records of P17787 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K58 | NMR structures of the first transmembrane domain of the neuronal acetylcholine receptor beta 2… | solution nmr | B | — | — |
| 2K58 | NMR structures of the first transmembrane domain of the neuronal acetylcholine receptor beta 2… | solution nmr | B | — | — |
| 2K59 | NMR structures of the second transmembrane domain of the neuronal acetylcholine receptor beta 2… | solution nmr | B | — | — |
| 2K59 | NMR structures of the second transmembrane domain of the neuronal acetylcholine receptor beta 2… | solution nmr | B | — | — |
| 2KSR | NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit | solution nmr | A | — | — |
| 2KSR | NMR structures of tm domain of the N-acetylcholine receptor B2 subunit | solution nmr | A | — | — |
| 2LM2 | NMR structures of the transmembrane domains of the AChR b2 subunit | solution nmr | A | — | — |
| 2LM2 | NMR structures of the transmembrane domains of the achr B2 subunit | solution nmr | A | — | — |
| 5KXI | X-ray structure of the human Alpha4Beta2 nicotinic receptor | x-ray diffraction | B, C, E | NCT, NAG | — |
| 5KXI | X-ray structure of the human ALPHA4BETA2 nicotinic receptor | x-ray diffraction | B, C, E | NCT, NAG | — |
| 6CNJ | Structure of the 2ALPHA3BETA stiochiometry of the human ALPHA4BETA2 nicotinic receptor | electron microscopy | B, C, E | NAG, NCT, Y01 | — |
| 6CNK | Structure of the 3ALPHA2BETA stiochiometry of the human ALPHA4BETA2 nicotinic receptor | electron microscopy | C, E | NAG, Y01, NCT | — |
| 6UR8 | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | electron microscopy | B, C, E | QMR, NAG | 19 (best 0.77) |
| 6UR8 | Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor in complex with varenicline | electron microscopy | B, C, E | QMR, NAG | — |
| 6USF | Cryoem structure of human ALPHA4BETA2 nicotinic acetylcholine receptor with varenicline in complex… | electron microscopy | B, C, E | NAG, QMR | — |
| 8ST0 | The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in… | electron microscopy | B, C, E | NAG, BMA, ACH | 17 (best 0.81) |
| 8ST1 | The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with… | electron microscopy | C, E | NAG, BMA, ACH | 16 (best 0.80) |
| 8ST3 | The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with… | electron microscopy | B, C, E | NAG, BMA, ACH, CA | 17 (best 0.82) |
| P17787 | AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit beta-2 (P17787) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 4 records
- ACH · Acetylcholine · in 3 records
- BMA · beta-D-mannopyranose · in 3 records
- QMR · Varenicline · in 3 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- CA · Calcium ion · in 1 record
Experiment against prediction
- 8ST3 chain E against the predicted model P17787: TM-score 0.99, RMSD 0.84 Å
- 8ST0 chain E against the predicted model P17787: TM-score 0.99, RMSD 0.86 Å
- 8ST1 chain E against the predicted model P17787: TM-score 0.99, RMSD 0.85 Å
- 8ST1 chain C against the predicted model P17787: TM-score 0.98, RMSD 0.91 Å
- 8ST0 chain C against the predicted model P17787: TM-score 0.98, RMSD 0.94 Å
- 8ST3 chain C against the predicted model P17787: TM-score 0.98, RMSD 0.93 Å
- 6CNK chain E against the predicted model P17787: TM-score 0.98, RMSD 1.10 Å
- 6CNJ chain E against the predicted model P17787: TM-score 0.98, RMSD 1.11 Å
- 8ST0 chain B against the predicted model P17787: TM-score 0.98, RMSD 1.15 Å
- 6CNK chain C against the predicted model P17787: TM-score 0.98, RMSD 1.14 Å
Elsewhere
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