Crystal structure of full-length human DCAF15-DDB1(DELTABPB)-DDA1- RBM39 in complex with indisulam

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• EF6 · N~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide · ligand · chains A, C
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6UD7 · Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q16531 · AlphaFold monomer V2.0 prediction for DNA damage-binding protein 1 (Q16531) · a predicted model of the same protein · chain B against A, TM-score 0.99
• Q66K64 · AlphaFold monomer V2.0 prediction for DDB1- and CUL4-associated factor 15 (Q66K64) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9BW61 · AlphaFold monomer V2.0 prediction for DET1- and DDB1-associated protein 1 (Q9BW61) · a predicted model of the same protein · chain D against A, TM-score 0.30

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q66K64
• Every structure of UniProt Q16531
• Every structure of UniProt Q7Z3L0
• Every structure of UniProt Q9BW61
• Elsewhere: RCSB PDB 6UD7 · PDBe 6UD7 · UniProt Q66K64 · UniProt Q16531 · UniProt Q7Z3L0 · UniProt Q9BW61