UniProt Q9BW61
DET1- and DDB1-associated protein 1 (Q9BW61)
DET1- and DDB1-associated protein 1 (UniProt Q9BW61): 23 experimental structures and 1 predicted model on GenesisL1, 66 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BW61
- Protein
- DET1- and DDB1-associated protein 1
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 66 · 13 records with a druggable one
Structures
24 records of Q9BW61 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DSZ | Crystal structure of DDB1 in complex with DET1- and DDB1-associated protein 1 (DDA1) | x-ray diffraction | C, D | — | 2 (best 0.78) |
| 6DSZ | Crystal structure of DDB1 in complex with DET1- and DDB1-associated protein 1 (DDA1) | x-ray diffraction | C, D | — | — |
| 6PAI | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 | x-ray diffraction | E | — | 5 (best 0.87) |
| 6PAI | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 | x-ray diffraction | E | — | — |
| 6Q0R | Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 | x-ray diffraction | E | — | 5 (best 0.80) |
| 6Q0R | Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 | x-ray diffraction | E | — | — |
| 6Q0V | Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 | x-ray diffraction | E | — | 6 (best 0.84) |
| 6Q0V | Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 | x-ray diffraction | E | — | — |
| 6Q0W | Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39 | x-ray diffraction | E | — | 5 (best 0.85) |
| 6Q0W | Structure of DDB1-DDA1-DCAF15 complex bound to indisulam and RBM39 | x-ray diffraction | E | — | — |
| 6SJ7 | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam | electron microscopy | D | — | 6 (best 0.82) |
| 6SJ7 | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and indisulam | electron microscopy | D | — | — |
| 6UD7 | Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam | x-ray diffraction | D | — | 7 (best 0.83) |
| 6UD7 | Crystal structure of full-length human DCAF15-DDB1(DELTABPB)-DDA1- RBM39 in complex with indisulam | x-ray diffraction | D | — | — |
| 6UE5 | Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with… | x-ray diffraction | D | — | 8 (best 0.83) |
| 6UE5 | Crystal structure of full-length human DCAF15-DDB1-deltapbp-DDA1-RBM39 in complex with… | x-ray diffraction | D | — | — |
| 8G46 | Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2 | electron microscopy | E | — | — |
| 8QH5 | CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1 | electron microscopy | C | — | 3 (best 0.79) |
| 8ROX | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12 | electron microscopy | D | — | 7 (best 0.81) |
| 8ROY | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24 | electron microscopy | D | — | 7 (best 0.75) |
| 8TL6 | Cryo-EM structure of DDB1deltaB-DDA1-DCAF5 | electron microscopy | E | — | 3 (best 0.75) |
| 9BZ0 | Structure of an STK19-containing TC-NER complex | electron microscopy | e | — | 2 (best 0.81) |
| 9FD2 | Structure of Pol II-TC-NER-STK19 complex | electron microscopy | c | — | — |
| Q9BW61 | AlphaFold monomer V2.0 prediction for DET1- and DDB1-associated protein 1 (Q9BW61) | predicted | A | — | — |
Experiment against prediction
- 8TL6 chain E against the predicted model Q9BW61: TM-score 0.53, RMSD 1.75 Å
- 8QH5 chain C against the predicted model Q9BW61: TM-score 0.36, RMSD 3.08 Å
- 6PAI chain E against the predicted model Q9BW61: TM-score 0.32, RMSD 3.67 Å
- 6PAI chain E against the predicted model Q9BW61: TM-score 0.32, RMSD 3.67 Å
- 6Q0W chain E against the predicted model Q9BW61: TM-score 0.31, RMSD 1.68 Å
- 6Q0W chain E against the predicted model Q9BW61: TM-score 0.31, RMSD 1.68 Å
- 6Q0V chain E against the predicted model Q9BW61: TM-score 0.31, RMSD 1.69 Å
- 6Q0V chain E against the predicted model Q9BW61: TM-score 0.31, RMSD 1.69 Å
- 8ROX chain D against the predicted model Q9BW61: TM-score 0.31, RMSD 3.38 Å
- 6Q0R chain E against the predicted model Q9BW61: TM-score 0.31, RMSD 2.91 Å
Elsewhere
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