UniProt Q16531
DNA damage-binding protein 1 (Q16531)
DNA damage-binding protein 1 (UniProt Q16531), EC 6.3.2.19: 204 experimental structures and 1 predicted model on GenesisL1, 32 ligands bound, 1,300 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q16531
- Protein
- DNA damage-binding protein 1
- EC
- 6.3.2.19
- Experimental structures
- 204
- Predicted models
- 1
- Ligands
- 32
- Pockets
- 1,300 · 95 records with a druggable one
Structures
205 records of Q16531 in the MolNFT archive: 204 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HYE | Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex | x-ray diffraction | A | — | — |
| 2HYE | Crystal structure of the DDB1-CUL4A-RBX1-SV5V complex | x-ray diffraction | A | — | — |
| 3E0C | Crystal Structure of DNA Damage-Binding protein 1(DDB1) | x-ray diffraction | A | — | — |
| 3E0C | Crystal structure of DNA damage-binding protein 1(DDB1) | x-ray diffraction | A | — | — |
| 3EI1 | Structure of hsDDB1-drDDB2 bound to a 14 bp 6-4 photoproduct containing DNA-duplex | x-ray diffraction | A | — | — |
| 3EI1 | Structure of HSDDB1-DRDDB2 bound to a 14 bp 6-4 photoproduct containing DNA-duplex | x-ray diffraction | A | — | — |
| 3EI2 | Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex | x-ray diffraction | A | — | — |
| 3EI2 | Structure of HSDDB1-DRDDB2 bound to a 16 bp abasic site containing DNA-duplex | x-ray diffraction | A | — | — |
| 3EI3 | Structure of the hsDDB1-drDDB2 complex | x-ray diffraction | A | — | — |
| 3EI3 | Structure of the HSDDB1-DRDDB2 complex | x-ray diffraction | A | — | — |
| 3EI4 | Structure of the hsDDB1-hsDDB2 complex | x-ray diffraction | A, C, E | — | — |
| 3EI4 | Structure of the HSDDB1-HSDDB2 complex | x-ray diffraction | A, C, E | — | — |
| 3I7H | Crystal Structure of DDB1 in Complex with the H-Box Motif of HBX | x-ray diffraction | A | — | — |
| 3I7H | Crystal structure of DDB1 in complex with the H-box motif of hbx | x-ray diffraction | A | — | — |
| 3I7K | Crystal Structure of DDB1 in Complex with the H-Box Motif of WHX | x-ray diffraction | A | — | — |
| 3I7K | Crystal structure of DDB1 in complex with the H-box motif of whx | x-ray diffraction | A | — | — |
| 3I7L | Crystal Structure of DDB1 in Complex with the H-Box Motif of DDB2 | x-ray diffraction | A | — | — |
| 3I7L | Crystal structure of DDB1 in complex with the H-box motif of DDB2 | x-ray diffraction | A | — | — |
| 3I7N | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDTC1 | x-ray diffraction | A | — | — |
| 3I7N | Crystal structure of DDB1 in complex with the H-box motif of WDTC1 | x-ray diffraction | A | — | — |
| 3I7O | Crystal Structure of DDB1 in Complex with the H-Box Motif of IQWD1 | x-ray diffraction | A | — | — |
| 3I7O | Crystal structure of DDB1 in complex with the H-box motif of IQWD1 | x-ray diffraction | A | — | — |
| 3I7P | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR40A | x-ray diffraction | A | — | — |
| 3I7P | Crystal structure of DDB1 in complex with the H-box motif of WDR40A | x-ray diffraction | A | — | — |
| 3I89 | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR22 | x-ray diffraction | A | — | — |
| 3I89 | Crystal structure of DDB1 in complex with the H-box motif of WDR22 | x-ray diffraction | A | — | — |
| 3I8C | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A | x-ray diffraction | A | — | — |
| 3I8C | Crystal structure of DDB1 in complex with the H-box motif of WDR21A | x-ray diffraction | A | — | — |
| 3I8E | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR42A | x-ray diffraction | A, B | — | — |
| 3I8E | Crystal structure of DDB1 in complex with the H-box motif of WDR42A | x-ray diffraction | A, B | — | — |
| 4A08 | Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution… | x-ray diffraction | A | — | — |
| 4A08 | Structure of HSDDB1-DRDDB2 bound to a 13 bp cpd-duplex (purine at D-1 position) at 3.0 a resolution… | x-ray diffraction | A | — | — |
| 4A09 | Structure of hsDDB1-drDDB2 bound to a 15 bp CPD-duplex (purine at D-1 position) at 3.1 A resolution… | x-ray diffraction | A | — | — |
| 4A09 | Structure of HSDDB1-DRDDB2 bound to a 15 bp cpd-duplex (purine at D-1 position) at 3.1 a resolution… | x-ray diffraction | A | — | — |
| 4A0A | Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.6 A… | x-ray diffraction | A | — | — |
| 4A0A | Structure of HSDDB1-DRDDB2 bound to a 16 bp cpd-duplex (pyrimidine at D-1 position) at 3.6 a… | x-ray diffraction | A | — | — |
| 4A0B | Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.8 A… | x-ray diffraction | A, C | — | — |
| 4A0B | Structure of HSDDB1-DRDDB2 bound to a 16 bp cpd-duplex (pyrimidine at D-1 position) at 3.8 a… | x-ray diffraction | A, C | — | — |
| 4A0K | Structure of DDB1-DDB2-CUL4A-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | C | — | — |
| 4A0K | Structure of DDB1-DDB2-CUL4A-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | C | — | — |
| 4A0L | Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | A, C | — | — |
| 4A0L | Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex | x-ray diffraction | A, C | — | — |
| 4A11 | Structure of the hsDDB1-hsCSA complex | x-ray diffraction | A | — | — |
| 4A11 | Structure of the HSDDB1-hscsa complex | x-ray diffraction | A | — | — |
| 4CI1 | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | x-ray diffraction | A | — | — |
| 4CI1 | Structure of the DDB1-crbn E3 ubiquitin ligase bound to thalidomide | x-ray diffraction | A | — | — |
| 4CI2 | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | x-ray diffraction | A | — | — |
| 4CI2 | Structure of the DDB1-crbn E3 ubiquitin ligase bound to lenalidomide | x-ray diffraction | A | — | — |
| 4CI3 | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | x-ray diffraction | A | — | — |
| 4CI3 | Structure of the DDB1-crbn E3 ubiquitin ligase bound to pomalidomide | x-ray diffraction | A | — | — |
| 4E54 | Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in… | x-ray diffraction | A | — | — |
| 4E54 | Damaged DNA induced UV-damaged DNA-binding protein (UV-ddb) dimerization and its roles in… | x-ray diffraction | A | — | — |
| 4E5Z | Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in… | x-ray diffraction | A | — | — |
| 4E5Z | Damaged DNA induced UV-damaged DNA-binding protein (UV-ddb) dimerization and its roles in… | x-ray diffraction | A | — | — |
| 4TZ4 | Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | x-ray diffraction | A | — | — |
| 4TZ4 | Crystal structure of human cereblon in complex with DDB1 and lenalidomide | x-ray diffraction | A | — | — |
| 5FQD | Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase | x-ray diffraction | A, D | — | 11 (best 0.87) |
| 5FQD | Structural basis of lenalidomide induced CK1A degradation by the CRL4CRBN ubiquitin ligase | x-ray diffraction | A, D | — | — |
| 5HXB | Cereblon in complex with DDB1, CC-885, and GSPT1 | x-ray diffraction | Y, B | — | 16 (best 0.86) |
| 5HXB | Cereblon in complex with DDB1, cc-885, and GSPT1 | x-ray diffraction | Y, B | — | — |
145 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 26 records
- UNX · Unknown atom or ion · in 3 records
- RC8 · (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl) amino]-9H-purin-2-yl}amino)butan-1-ol · in 2 records
- RMF · ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine · in 2 records
- RQL · (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol · in 2 records
- A1ALA · 1H-indol-6-amine · in 1 record
- A1ALB · 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)aniline · in 1 record
- RKO · 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide · in 1 record
- RLC · (2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RMX · 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide · in 1 record
- RNF · (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RNU · ~{N}-(5-methyl-2,3-dihydro-1,3-thiazol-2-yl)-3-(5-methylfuran-2-yl)carbonyl-1,3-thiazolidine-4-carboxamide · in 1 record
- RP9 · ~{N}-(5-bromanylpyridin-2-yl)-3-(4-oxidanylidenequinazolin-3-yl)propanamide · in 1 record
- RPW · 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide · in 1 record
- RQ5 · 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RQE · ~{N}-(1~{H}-benzimidazol-2-ylmethyl)-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine · in 1 record
- RQU · ~{N}-[2-(2-methoxyphenyl)ethyl]-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]ethanamide · in 1 record
- RR9 · 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one · in 1 record
- RRC · R-roscovitine · in 1 record
- RS5 · 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- RSI · 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine · in 1 record
- RSU · (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RUW · (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RV6 · (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol · in 1 record
- RVH · (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide · in 1 record
- RVQ · ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-2-morpholin-4-yl-9-propan-2-yl-purin-6-amine · in 1 record
- RVU · ~{N}-(1~{H}-benzimidazol-2-yl)-1-(2-methoxy-5-methyl-phenyl)-5-oxidanylidene-pyrrolidine-3-carboxamide · in 1 record
- RW6 · 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one · in 1 record
- RWE · (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
- RWN · (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol · in 1 record
Experiment against prediction
- 8BUO chain D against the predicted model Q3U1J4: TM-score 0.99, RMSD 0.74 Å
- 8BUO chain G against the predicted model Q3U1J4: TM-score 0.99, RMSD 0.86 Å
- 8TL6 chain A against the predicted model Q16531: TM-score 0.99, RMSD 0.88 Å
- 8G46 chain A against the predicted model Q16531: TM-score 0.99, RMSD 0.86 Å
- 8BUO chain A against the predicted model Q3U1J4: TM-score 0.99, RMSD 0.94 Å
- 8B3F chain d against the predicted model Q16531: TM-score 0.99, RMSD 0.89 Å
- 7OOB chain d against the predicted model Q16531: TM-score 0.99, RMSD 0.92 Å
- 7OOB chain d against the predicted model Q16531: TM-score 0.99, RMSD 0.92 Å
- 8BUE chain D against the predicted model Q16531: TM-score 0.99, RMSD 0.98 Å
- 8BUI chain D against the predicted model Q16531: TM-score 0.99, RMSD 0.99 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.