Ligand · RQL
RQL · (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol
RQL, (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol (C21 H22 Cl2 N10 O, 501.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries).…
- Component
- RQL
- Formula
- C21 H22 Cl2 N10 O
- Class
- ligand
- Structures
- 2
- PDB entries
- 2
Binding sites
RQL in 2 structures; the first of them:
- 8BU1 · Structure of DDB1 bound to DS17-engaged CDK12-cyclin K · RQL B1101 · binds ASN907, ASN908, ILE909, ARG928, ARG947, ILE732, ILE733, GLY734 and 13 more
- 8BU4 · Structure of DDB1 bound to DS22-engaged CDK12-cyclin K · RQL B1101 · binds ASN907, ASN908, ILE909, ARG928, ARG947, ILE732, ILE733, GLY734 and 15 more
Residues it binds most
ILE 6, ASP 6, ALA 6, ARG 6, ASN 6, VAL 6, GLU 6, GLY 6, HIS 6, LEU 6 (residue and the binding sites it lines).
Found with
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