UniProt Q66K64
DDB1- and CUL4-associated factor 15 (Q66K64)
DDB1- and CUL4-associated factor 15 (UniProt Q66K64): 11 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q66K64
- Protein
- DDB1- and CUL4-associated factor 15
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 49 · 4 records with a druggable one
Structures
12 records of Q66K64 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PAI | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 | x-ray diffraction | C | O6M, ZN | — |
| 6Q0R | Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 | x-ray diffraction | B, C | OXM, O6M, ZN | — |
| 6Q0V | Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 | x-ray diffraction | B, C | P7M, ZN | — |
| 6Q0W | Structure of DDB1-DDA1-DCAF15 complex bound to indisulam and RBM39 | x-ray diffraction | B, C | EF6, ZN | — |
| 6SJ7 | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam | electron microscopy | A | EF6 | 14 (best 0.82) |
| 6SJ7 | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and indisulam | electron microscopy | A | EF6 | — |
| 6UD7 | Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam | x-ray diffraction | A | EF6 | 13 (best 0.84) |
| 6UD7 | Crystal structure of full-length human DCAF15-DDB1(DELTABPB)-DDA1- RBM39 in complex with indisulam | x-ray diffraction | A | EF6 | — |
| 6UE5 | Crystal structure of full-length human DCAF15-DDB1-deltapbp-DDA1-RBM39 in complex with… | x-ray diffraction | A | Q5J | — |
| 8ROX | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12 | electron microscopy | A | A1H17 | 8 (best 0.81) |
| 8ROY | Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24 | electron microscopy | A | A1H18 | 14 (best 0.81) |
| Q66K64 | AlphaFold monomer V2.0 prediction for DDB1- and CUL4-associated factor 15 (Q66K64) | predicted | A | — | — |
Ligands
- EF6 · N~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide · in 5 records
- ZN · Zinc ion · in 4 records
- O6M · 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide · in 2 records
- A1H17 · 5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-~{N},~{N},3-trimethyl-furan-2-carboxamide;ethane · in 1 record
- A1H18 · 1-[5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-3-methyl-furan-2-yl]carbonyl-~{N}-methyl-piperidine-4-carboxamide · in 1 record
- OXM · Oxamic acid · in 1 record
- P7M · N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichlorobenzamide · in 1 record
- Q5J · 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl) benzene-1-sulfonamide · in 1 record
Experiment against prediction
- 6Q0R chain B against the predicted model Q66K64: TM-score 0.99, RMSD 0.62 Å
- 6Q0V chain B against the predicted model Q66K64: TM-score 0.99, RMSD 0.63 Å
- 6Q0W chain B against the predicted model Q66K64: TM-score 0.99, RMSD 0.65 Å
- 6PAI chain C against the predicted model Q66K64: TM-score 0.99, RMSD 0.93 Å
- 6Q0R chain C against the predicted model Q66K64: TM-score 0.99, RMSD 0.65 Å
- 6UD7 chain A against the predicted model Q66K64: TM-score 0.98, RMSD 1.14 Å
- 6UD7 chain A against the predicted model Q66K64: TM-score 0.98, RMSD 1.14 Å
- 6UE5 chain A against the predicted model Q66K64: TM-score 0.98, RMSD 1.20 Å
- 8ROY chain A against the predicted model Q66K64: TM-score 0.97, RMSD 1.05 Å
- 6Q0V chain C against the predicted model Q66K64: TM-score 0.97, RMSD 0.94 Å
Elsewhere
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