MolNFT v1 · #165778 · protein
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form
6U6C: “Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form”. X-ray diffraction, 3 ligands (PZV, K, NA). MolNFT v1 #165778 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6U6C
- Type
- protein
- Length
- 2,614 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P9WFY1, P9WFX9
- Ligands
- PZV, K, NA
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, G | — | protein | 249 | — | P9WFY1 |
| B | — | protein | 406 | — | P9WFX9 |
| D, F, H | — | protein | 405 | — | P9WFX9 |
| E | — | protein | 246 | — | P9WFY1 |
Ligands and binding sites
- PZV · 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide · ligand · 4 copies · chains A, B, C, D, E, F, G, H
- K · Potassium ion · metal · 8 copies · chains B, C, D, F, G, H
- NA · Sodium ion · metal · chains B, F, H
- FMT · Formic acid · additive · 92 copies · chains A, B, D, F, H, C, E, G
- EDO · 1,2-ethanediol · additive · 24 copies · chains A, B, D, C, E, F, G, H
- MLI · Malonate ion · additive · 6 copies · chains A, C, E, D, F, G, H
- ACT · Acetate ion · additive · 5 copies · chains A, B, F, G, H
- PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains B, F, H, G
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 4 copies · chains B, D, F, H
- PGE · Triethylene glycol · additive · 2 copies · chains D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6U6C · Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and… · the same entry in another collection · chain A against A, TM-score 1.00
- P9WFY1 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P9WFY1) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P9WFX9 · AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain (P9WFX9) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WFY1
- Every structure of UniProt P9WFX9
- Elsewhere: RCSB PDB 6U6C · PDBe 6U6C · UniProt P9WFY1 · UniProt P9WFX9
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