UniProt P9WFX9
Tryptophan synthase beta chain (P9WFX9)
Tryptophan synthase beta chain (UniProt P9WFX9), EC 4.2.1.20: 24 experimental structures on GenesisL1, 11 ligands bound, 218 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P9WFX9
- Protein
- Tryptophan synthase beta chain
- EC
- 4.2.1.20
- Experimental structures
- 24
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 218 · 11 records with a druggable one
Structures
24 records of P9WFX9 in the MolNFT archive: 24 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OCW | Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222 | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | P1T | 20 (best 0.81) |
| 5OCW | Structure of mycobacterium tuberculosis tryptophan synthase in space group F222 | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 5TCF | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form | x-ray diffraction | B, H, F, D | K | — |
| 5TCG | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form | x-ray diffraction | B, H, F, D | P1T, CS | 20 (best 0.83) |
| 5TCG | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form | x-ray diffraction | B, H, F, D | CS | — |
| 5TCH | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, TrpA-G66V mutant | x-ray diffraction | B, H, F, D | — | 19 (best 0.88) |
| 5TCH | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, trpa-G66V mutant | x-ray diffraction | B, H, F, D | — | — |
| 5TCI | Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form | x-ray diffraction | B, H, F, D | 79V | 19 (best 0.88) |
| 5TCI | Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form | x-ray diffraction | B, H, F, D | 79V | — |
| 5TCJ | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form | x-ray diffraction | B, H, F, D | P1T, CS, 79V | 20 (best 0.85) |
| 5TCJ | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form | x-ray diffraction | B, H, F, D | CS, 79V | — |
| 6DWE | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound… | x-ray diffraction | B, H, F, D | P1T, CS, HDJ | 20 (best 0.82) |
| 6DWE | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound… | x-ray diffraction | B, H, F, D | CS, HDJ | — |
| 6E9P | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound | x-ray diffraction | B, D, F, H | HDJ, MLT | 20 (best 0.83) |
| 6E9P | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound | x-ray diffraction | B, D, F, H | HDJ, MLT | — |
| 6U6C | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form | x-ray diffraction | B, D, F, H | PZV, P1T, K, NA | 20 (best 0.82) |
| 6U6C | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form | x-ray diffraction | B, D, F, H | PZV, K, NA | — |
| 6UAP | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound | x-ray diffraction | B, D, F, H | H9V, MLT | 20 (best 0.83) |
| 6UAP | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound | x-ray diffraction | B, D, F, H | H9V, MLT | — |
| 6UB9 | Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND… | x-ray diffraction | B, D, F, H | P1T, H9V, CS | 20 (best 0.82) |
| 6UB9 | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD6309-bound… | x-ray diffraction | B, D, F, H | H9V, CS | — |
| 6USA | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form | x-ray diffraction | B, D, F, H | PZJ, P1T, K, SO4, NA | 20 (best 0.84) |
| 6USA | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form | x-ray diffraction | B, D, F, H | PZJ, K, SO4, NA | — |
| P9WFX9 | AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain (P9WFX9) | — | — | — |
Ligands
- CS · Cesium ion · in 8 records
- P1T · 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid · in 7 records
- K · Potassium ion · in 5 records
- 79V · (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile · in 4 records
- H9V · (2R,3S,4R)-3-(4'-chloro-2',6'-difluoro[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile · in 4 records
- HDJ · (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile · in 4 records
- MLT · D-malate · in 4 records
- NA · Sodium ion · in 4 records
- PZJ · (3R,4R)-4-[4-(2-Chlorophenyl)piperazin-1-yl]-1,1-dioxothiolan-3-ol · in 2 records
- PZV · 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide · in 2 records
- SO4 · Sulfate ion · in 2 records
Elsewhere
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