UniProt P9WFY1
Tryptophan synthase alpha chain (P9WFY1)
Tryptophan synthase alpha chain (UniProt P9WFY1), EC 4.2.1.20: 20 experimental structures on GenesisL1, 7 ligands bound, 73 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P9WFY1
- Protein
- Tryptophan synthase alpha chain
- EC
- 4.2.1.20
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 73 · 7 records with a druggable one
Structures
20 records of P9WFY1 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OCW | Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222 | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | 12 (best 0.81) |
| 5OCW | Structure of mycobacterium tuberculosis tryptophan synthase in space group F222 | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | — |
| 5TCF | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form | x-ray diffraction | A, G, E, C | — | — |
| 5TCG | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form | x-ray diffraction | A, G, E, C | — | 7 (best 0.78) |
| 5TCG | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form | x-ray diffraction | A, G, E, C | — | — |
| 5TCH | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, TrpA-G66V mutant | x-ray diffraction | A, G, E, C | — | 12 (best 0.86) |
| 5TCH | Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, trpa-G66V mutant | x-ray diffraction | A, G, E, C | — | — |
| 5TCI | Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form | x-ray diffraction | A, G, E, C | 79V | 11 (best 0.88) |
| 5TCI | Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form | x-ray diffraction | A, G, E, C | 79V | — |
| 5TCJ | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form | x-ray diffraction | A, G, E, C | 79V | 9 (best 0.81) |
| 5TCJ | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form | x-ray diffraction | A, G, E, C | 79V | — |
| 6DWE | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound… | x-ray diffraction | A, G, E, C | HDJ | — |
| 6E9P | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound | x-ray diffraction | A, C, E, G | HDJ | 13 (best 0.83) |
| 6E9P | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound | x-ray diffraction | A, C, E, G | HDJ | — |
| 6U6C | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form | x-ray diffraction | A, C, E, G | PZV, K | — |
| 6UAP | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound | x-ray diffraction | A, C, E, G | H9V | — |
| 6UB9 | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD6309-bound… | x-ray diffraction | A, C, E, G | H9V | — |
| 6USA | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form | x-ray diffraction | A, C, E, G | PZJ, K, SO4 | 9 (best 0.82) |
| 6USA | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK1-bound form | x-ray diffraction | A, C, E, G | PZJ, K, SO4 | — |
| P9WFY1 | AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P9WFY1) | — | — | — |
Ligands
- 79V · (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile · in 4 records
- HDJ · (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile · in 3 records
- K · Potassium ion · in 3 records
- H9V · (2R,3S,4R)-3-(4'-chloro-2',6'-difluoro[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile · in 2 records
- PZJ · (3R,4R)-4-[4-(2-Chlorophenyl)piperazin-1-yl]-1,1-dioxothiolan-3-ol · in 2 records
- SO4 · Sulfate ion · in 2 records
- PZV · 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.