MolNFT v1 · #165555 · protein
Crystal structure of aspergillus fumigatus calcineurin a, calcineurin B, FKBP12 and FK506 (tacrolimus)
6TZ7: “Crystal structure of aspergillus fumigatus calcineurin a, calcineurin B, FKBP12 and FK506 (tacrolimus)”. X-ray diffraction, 5 ligands (FK5, CA, ZN). MolNFT v1 #165555 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TZ7
- Type
- protein
- Length
- 597 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q4WUR1, Q4WDF2, Q4WLV6
- Ligands
- FK5, CA, ZN, FE, PO4
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 358 | — | Q4WUR1 |
| B | — | protein | 122 | — | Q4WDF2 |
| C | — | protein | 117 | — | Q4WLV6 |
Ligands and binding sites
- FK5 · 8-deethyl-8-[but-3-enyl]-ascomycin · ligand · chains A, B, C
- CA · Calcium ion · metal · 3 copies · chains B
- ZN · Zinc ion · metal · chains A
- FE · Fe (III) ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TZ7 · Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506… · the same entry in another collection · chain A against A, TM-score 1.00
- Q4WUR1 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2B catalytic… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q4WLV6 · AlphaFold monomer V2.0 prediction for FK506-binding protein 1A (Q4WLV6) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4WUR1
- Every structure of UniProt Q4WDF2
- Every structure of UniProt Q4WLV6
- Elsewhere: RCSB PDB 6TZ7 · PDBe 6TZ7 · UniProt Q4WUR1 · UniProt Q4WDF2 · UniProt Q4WLV6
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