UniProt Q4WLV6
FK506-binding protein 1A (Q4WLV6)
FK506-binding protein 1A (UniProt Q4WLV6), EC 5.2.1.8: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4WLV6
- Protein
- FK506-binding protein 1A
- EC
- 5.2.1.8
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 25 · 5 records with a druggable one
Structures
13 records of Q4WLV6 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HWB | Aspergillus fumigatus FKBP12 apo protein in P212121 space group | x-ray diffraction | A, B | SO4 | 3 (best 0.50) |
| 5HWB | Aspergillus fumigatus FKBP12 apo protein in P212121 space group | x-ray diffraction | A, B | SO4 | 3 (best 0.50) |
| 5HWC | Aspergillus fumigatus FKBP12 P90G protein bound with FK506 in P212121 space group | x-ray diffraction | A | FK5 | 1 (best 0.43) |
| 5HWC | Aspergillus fumigatus FKBP12 P90G protein bound with FK506 in P212121 space group | x-ray diffraction | A | FK5 | 1 (best 0.43) |
| 5J6E | Structure of disulfide crosslinked A. fumigatus FKBP12(V91C) | x-ray diffraction | A, B | — | 4 (best 0.45) |
| 5J6E | Structure of disulfide crosslinked a. fumigatus FKBP12(V91C) | x-ray diffraction | A, B | — | 4 (best 0.45) |
| 6TZ7 | Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506… | x-ray diffraction | C | FK5 | 3 (best 0.79) |
| 6TZ7 | Crystal structure of aspergillus fumigatus calcineurin a, calcineurin B, FKBP12 and FK506… | x-ray diffraction | C | FK5 | — |
| 6VCV | Aspergillus fumigatus FKBP12 protein bound with APX879 in P1 space group | x-ray diffraction | A, B | R27 | 4 (best 0.60) |
| 6VCV | Aspergillus fumigatus FKBP12 protein bound with APX879 in P1 space group | x-ray diffraction | A, B | R27 | — |
| 7U0S | Crystal Structure of FK506-binding protein 1A from Aspergillus fumigatus Bound to Ascomycin | x-ray diffraction | A, B | KXX, SO4 | 2 (best 0.55) |
| 7U0S | Crystal structure of FK506-binding protein 1A from aspergillus fumigatus bound to ascomycin | x-ray diffraction | A, B | KXX, SO4 | — |
| Q4WLV6 | AlphaFold monomer V2.0 prediction for FK506-binding protein 1A (Q4WLV6) | predicted | A | — | — |
Ligands
- FK5 · 8-deethyl-8-[but-3-enyl]-ascomycin · in 4 records
- SO4 · Sulfate ion · in 4 records
- KXX · (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,22r,26as)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4, 10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19, 24,25,26,26A-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone · in 2 records
- R27 · N'-[(3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4, 10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23, 24,25,26,26A-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide · in 2 records
Experiment against prediction
- 7U0S chain A against the predicted model Q4WLV6: TM-score 0.89, RMSD 0.45 Å
- 7U0S chain A against the predicted model Q4WLV6: TM-score 0.89, RMSD 0.45 Å
- 6VCV chain A against the predicted model Q4WLV6: TM-score 0.99, RMSD 0.56 Å
- 6VCV chain A against the predicted model Q4WLV6: TM-score 0.99, RMSD 0.56 Å
- 7U0S chain B against the predicted model Q4WLV6: TM-score 0.97, RMSD 0.51 Å
- 7U0S chain B against the predicted model Q4WLV6: TM-score 0.97, RMSD 0.51 Å
- 5HWC chain A against the predicted model Q4WLV6: TM-score 0.98, RMSD 0.61 Å
- 5HWC chain A against the predicted model Q4WLV6: TM-score 0.98, RMSD 0.61 Å
- 6VCV chain B against the predicted model Q4WLV6: TM-score 0.98, RMSD 0.58 Å
- 6VCV chain B against the predicted model Q4WLV6: TM-score 0.98, RMSD 0.58 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.