Ligand · R27
R27 · N'-[(3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4, 10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23, 24,25,26,26A-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide
R27, N'-[(3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4…
- Component
- R27
- Formula
- C46 H73 N3 O12
- Class
- ligand
- Structures
- 3
- PDB entries
- 3
Binding sites
R27 in 3 structures; the first of them:
- 6VCT · Mucor circinelloides FKBP12 protein bound with APX879 in C2221 space group · R27 A201 · binds TYR27, PHE37, ASP38, PHE47, GLN55, VAL56, ILE57, TRP60 and 6 more
- 6VCU · Homo sapiens FKBP12 protein bound with APX879 in P32 space group · R27 A203 · binds TYR26, PHE36, ASP37, ARG42, PHE46, GLU54, VAL55, ILE56 and 13 more
- 6VCV · Aspergillus fumigatus FKBP12 protein bound with APX879 in P1 space group · R27 A201 · binds TYR27, PHE37, ASP38, ARG43, PHE47, ARG55, VAL56, ILE57 and 6 more
Residues it binds most
PHE 7, TYR 7, ILE 7, HIS 4, ARG 7, VAL 7, ASP 7, TRP 7, GLY 6, ALA 5 (residue and the binding sites it lines).
Found with
- ACT · Acetate ion
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