Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2770372

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• OLA · Oleic acid · ligand · 7 copies · chains A
• KO5 · (2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl) butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih ydro-1,4-benzoxazine-2-carboxylic acid · ligand · chains A
• CLR · Cholesterol · ligand · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 13 copies · chains A
• 1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6RZ9 · Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NS75 · AlphaFold monomer V2.0 prediction for cysteinyl leukotriene receptor 2 (Q9NS75) · a predicted model of the same protein · chain A against A, TM-score 0.78
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.22

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NS75
• Every structure of UniProt P0ABE7
• Elsewhere: RCSB PDB 6RZ9 · PDBe 6RZ9 · UniProt Q9NS75 · UniProt P0ABE7