UniProt Q9NS75
Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2 (Q9NS75)
Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2 (UniProt Q9NS75): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 12 pockets. Binding sites, druggability…
- UniProt
- Q9NS75
- Protein
- Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene…
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 12 · 4 records with a druggable one
Structures
9 records of Q9NS75 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6RZ6 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (C2221… | x-ray diffraction | A | KNW, CLR, OLA | 3 (best 0.80) |
| 6RZ6 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2570366 (C2221… | x-ray diffraction | A | KNW, CLR, OLA | — |
| 6RZ7 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222… | x-ray diffraction | A | KNW, CLR, OLA | 3 (best 0.80) |
| 6RZ7 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2570366 (F222… | x-ray diffraction | A | KNW, CLR, OLA | — |
| 6RZ8 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2080365 | x-ray diffraction | A | KNZ, OLA | 3 (best 0.78) |
| 6RZ8 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2080365 | x-ray diffraction | A | KNZ, OLA | — |
| 6RZ9 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372 | x-ray diffraction | A | KO5, CLR, OLA | 3 (best 0.79) |
| 6RZ9 | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2770372 | x-ray diffraction | A | KO5, CLR, OLA | — |
| Q9NS75 | AlphaFold monomer V2.0 prediction for cysteinyl leukotriene receptor 2 (Q9NS75) | predicted | A | — | — |
Ligands
- OLA · Oleic acid · in 8 records
- CLR · Cholesterol · in 6 records
- KNW · (2~{S})-8-[[4-[4-(2-chloranyl-5-fluoranyl-phenyl) butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3- dihydro-1,4-benzoxazine-2-carboxylic acid · in 4 records
- KNZ · (2~{S})-8-[[4-[4-[2,3-bis(fluoranyl)phenoxy]butoxy]-2-fluoranyl-phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-but yl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid · in 2 records
- KO5 · (2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl) butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dih ydro-1,4-benzoxazine-2-carboxylic acid · in 2 records
Experiment against prediction
- 6RZ6 chain A against the predicted model Q9NS75: TM-score 0.78, RMSD 1.20 Å
- 6RZ6 chain A against the predicted model Q9NS75: TM-score 0.78, RMSD 1.20 Å
- 6RZ9 chain A against the predicted model Q9NS75: TM-score 0.78, RMSD 1.13 Å
- 6RZ9 chain A against the predicted model Q9NS75: TM-score 0.78, RMSD 1.13 Å
- 6RZ7 chain A against the predicted model Q9NS75: TM-score 0.77, RMSD 1.09 Å
- 6RZ7 chain A against the predicted model Q9NS75: TM-score 0.77, RMSD 1.09 Å
- 6RZ8 chain A against the predicted model Q9NS75: TM-score 0.73, RMSD 1.60 Å
- 6RZ8 chain A against the predicted model Q9NS75: TM-score 0.73, RMSD 1.60 Å
- 6RZ8 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 1.74 Å
- 6RZ8 chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 1.74 Å
Elsewhere
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