MolNFT v1 · #160813 · protein
Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with nicotine
6PV7: “Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with nicotine”. Electron microscopy, 6 ligands (Y01, NCT, NAG). MolNFT v1 #160813 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6PV7
- Type
- protein
- Length
- 2,379 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P32297, A0A3W4NZ06, P30926
- Ligands
- Y01, NCT, NAG, MAN, BMA, NA
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | — | protein | 387 | — | P32297, A0A3W4NZ06 |
| B, E | — | protein | 388 | — | A0A3W4NZ06, P30926 |
| C | — | protein | 385 | — | A0A3W4NZ06, P30926 |
| F, H | — | protein | 117 | — | — |
| G, I | — | protein | 105 | — | — |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 10 copies · chains A, E, B, C, D
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · ligand · 2 copies · chains A, B, D, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 26 copies · chains A, B, H, C, D, F, E
- MAN · alpha-D-mannopyranose · sugar · 10 copies · chains D
- BMA · beta-D-mannopyranose · sugar · 8 copies
- NA · Sodium ion · metal
- DD9 · nonane · additive
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6PV7 · Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine · the same entry in another collection · chain I against I, TM-score 1.00
- P32297 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-3… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P30926 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit beta-4… · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32297
- Every structure of UniProt A0A3W4NZ06
- Every structure of UniProt P30926
- Elsewhere: RCSB PDB 6PV7 · PDBe 6PV7 · UniProt P32297 · UniProt A0A3W4NZ06 · UniProt P30926
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