UniProt P30926
Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 (P30926)
Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 (UniProt P30926): 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 40 pockets. Binding sites, druggability…
- UniProt
- P30926
- Protein
- Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble…
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 40 · 2 records with a druggable one
Structures
5 records of P30926 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PV7 | Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine | electron microscopy | B, C, E | NAG, MAN, NCT, Y01, NA | 20 (best 0.83) |
| 6PV7 | Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with nicotine | electron microscopy | B, C, E | NAG, NCT, Y01 | — |
| 6PV8 | Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 | electron microscopy | B, C, E | NAG, MAN, P1M, Y01, NA | 20 (best 0.82) |
| 6PV8 | Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with at- 1001 | electron microscopy | B, C, E | NAG, MAN, P1M, Y01, NA | — |
| P30926 | AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit beta-4 (P30926) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- MAN · alpha-D-mannopyranose · in 3 records
- NA · Sodium ion · in 3 records
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 2 records
- P1M · (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine · in 2 records
Experiment against prediction
- 6PV7 chain E against the predicted model P30926: TM-score 0.97, RMSD 1.33 Å
- 6PV7 chain E against the predicted model P30926: TM-score 0.97, RMSD 1.33 Å
- 6PV8 chain C against the predicted model P30926: TM-score 0.97, RMSD 1.33 Å
- 6PV8 chain C against the predicted model P30926: TM-score 0.97, RMSD 1.33 Å
- 6PV8 chain E against the predicted model P30926: TM-score 0.97, RMSD 1.36 Å
- 6PV8 chain E against the predicted model P30926: TM-score 0.97, RMSD 1.36 Å
- 6PV8 chain B against the predicted model P30926: TM-score 0.97, RMSD 1.35 Å
- 6PV8 chain B against the predicted model P30926: TM-score 0.97, RMSD 1.35 Å
- 6PV7 chain B against the predicted model P30926: TM-score 0.97, RMSD 1.35 Å
- 6PV7 chain B against the predicted model P30926: TM-score 0.97, RMSD 1.35 Å
Elsewhere
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