UniProt P32297
soluble acetylcholine receptor, neuronal acetylcholine receptor subunit alpha-3 chimera (P32297)
soluble acetylcholine receptor, neuronal acetylcholine receptor subunit alpha-3 chimera (UniProt P32297): 10 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 174 pockets. Binding sites, druggability…
- UniProt
- P32297
- Protein
- soluble acetylcholine receptor, neuronal acetylcholine receptor subunit alpha-3…
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 174 · 10 records with a druggable one
Structures
11 records of P32297 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ZK4 | Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP)… | x-ray diffraction | A, B, C, D, E | MG, SO4, TII | 17 (best 0.66) |
| 4ZK4 | Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp)… | x-ray diffraction | A, B, C, D, E | MG, SO4, TII | 17 (best 0.66) |
| 5SYO | Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP)… | x-ray diffraction | A, B, C, D, E | C5E | 19 (best 0.66) |
| 5SYO | Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp)… | x-ray diffraction | A, B, C, D, E | C5E | 19 (best 0.66) |
| 5TVC | Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP)… | x-ray diffraction | A, B, C, D, E | SO4, 7LB | 15 (best 0.66) |
| 5TVC | Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp)… | x-ray diffraction | A, B, C, D, E | SO4, 7LB | 15 (best 0.66) |
| 6PV7 | Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine | electron microscopy | A, D | NAG, BMA, MAN, NCT, Y01, NA | 17 (best 0.83) |
| 6PV7 | Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with nicotine | electron microscopy | A, D | NAG, BMA, MAN, NCT, Y01, NA | 17 (best 0.83) |
| 6PV8 | Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 | electron microscopy | A, D | NAG, BMA, MAN, P1M, Y01, NA | 18 (best 0.82) |
| 6PV8 | Human ALPHA3BETA4 nicotinic acetylcholine receptor in complex with at- 1001 | electron microscopy | A, D | NAG, BMA, MAN, P1M, Y01, NA | 18 (best 0.82) |
| P32297 | AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-3 (P32297) | predicted | A | — | 2 (best 0.34) |
Ligands
- BMA · beta-D-mannopyranose · in 4 records
- MAN · alpha-D-mannopyranose · in 4 records
- NA · Sodium ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- SO4 · Sulfate ion · in 4 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- 7LB · (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine · in 2 records
- C5E · (1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one · in 2 records
- MG · Magnesium ion · in 2 records
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 2 records
- P1M · (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine · in 2 records
- TII · (5R)-1-methyl-7-[5-(propan-2-yloxy)pyridin-3-yl]-1,7-diazaspiro[4.4]nonane · in 2 records
Experiment against prediction
- 6PV8 chain D against the predicted model P32297: TM-score 0.98, RMSD 0.90 Å
- 6PV8 chain D against the predicted model P32297: TM-score 0.98, RMSD 0.90 Å
- 6PV8 chain A against the predicted model P32297: TM-score 0.98, RMSD 0.93 Å
- 6PV8 chain A against the predicted model P32297: TM-score 0.98, RMSD 0.93 Å
- 6PV7 chain A against the predicted model P32297: TM-score 0.98, RMSD 0.95 Å
- 6PV7 chain A against the predicted model P32297: TM-score 0.98, RMSD 0.95 Å
- 6PV7 chain D against the predicted model P32297: TM-score 0.98, RMSD 0.96 Å
- 6PV7 chain D against the predicted model P32297: TM-score 0.98, RMSD 0.96 Å
- 5SYO chain C against the predicted model P32297: TM-score 0.92, RMSD 2.03 Å
- 5SYO chain C against the predicted model P32297: TM-score 0.92, RMSD 2.03 Å
Elsewhere
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