MolNFT v1 · #15822 · protein

Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity, II. structure of the active site with ADP or ATP bound to wild type and mutant ATPase fragment

1NGI · Heat-shock cognate 70 kd protein: “Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity, II. structure of…”. X-ray diffraction, 2 ligands (ANP, CA), 1 pocket (best druggability 0.78). MolNFT v1…

PDB: 1NGI
Type: protein
Length: 378 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat-shock cognate 70 kd protein
EC: 3.6.1.3
UniProt: P19120
Ligands: ANP, CA
Pockets: 1 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat-shock cognate 70 kd protein (EC 3.6.1.3)	protein	378	40% helix, 29% strand	P19120

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	755	0.78	0.82	78	CA, ANP

Compared structures

1NGI · Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity… · the same entry in another collection · chain A against A, TM-score 1.00
P19120 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P19120) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19120
Elsewhere: RCSB PDB 1NGI · PDBe 1NGI · UniProt P19120

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